test 1 review prep Flashcards
functions of endocrine system
- Reproduction
- ? and Development
- ? Balance of blood
- ? Balance of blood
- ? balance in blood
- Regulation of cellular ?
- Regulation of cellular ? balance (Cellular Respiration)
- Mobilization of ? system
growth, water, electrolyte, nutrient, metabolism, energy, immune
Endocrine system is ? than Nervous system
slower
endocrine system initiates responses ? and has ? duration responses. it activates via ? at ? locations. the hormones act over ? distances
slower, long, hormones, diffuse, long
water soluble:
- use ? ? systems
- all ? ? based hormones (except TH) are water soluble and cannot diffuse across ? cell membrane
second messenger, amino acid, lipid
fat soluble hormones:
- use ? ? activation
direct gene
- Water soluble hormone, ? messenger, binds to ? on plasma membrane of target cell
- ? receptor sets off a series of reactions (?) that activates Cyclic AMP
- Cyclic AMP activates protein ?
- Water soluble protein hormones cause intracellular ? cascade that has a huge amplification effect
- Number of product molecules ? dramatically so that a single hormone can generate millions of final product molecules
first, receptor, activated, cascade, kinase, enzymatic, increase
- ? Soluble, ? hormones and ? hormones use intracellular receptors to
stimulate Direct Gene Activation. - They diffuse through ? ? into target cells and bind with intracellular receptors forming hormone-receptor complex that diffuses into the nucleus.
- The receptor binds to specific region of DNA and “turns on” a gene that initiates DNA ? and ? to produce a specific protein
lipid, steroid, thyroid, plasma membrane, transcription, translation
? stimuli is the changing blood levels of ions and nutrients directly stimulate secretion of hormones
humoral
? stimuli is when nervous impulse stimulate hormone release
neural
? stimuli occurs when many endocrine glands release their hormones in response to hormones produced by other endocrine glands
hormonal
Most Synthesis and Release of Hormones is Controlled by ? Feedback Systems
negative
Cyclic AMP second-messenger mechanism of water-soluble hormones order:
? binds to receptor
receptor activates ? protein
G protein activates ? cyclase
adenylate cyclase converts ATP to ? (2nd messenger)
cAMP activates protein ?
hormone, G, adenylate, cAMP, kinases
target cells are those cells with ? for the ?.
receptors, hormone
In General, Steroid hormones and thyroid hormone are ? in plasma because they are derived from cholesterol. Steroid hormones circulate in blood bound to plasma proteins and have a ? (longer/shorter) half-life bc all steroid hormones are derived from cholesterol.
insoluble, longer
In General, Protein hormones are ? in plasma. Protein hormones circulate without protein carriers and protein hormones are water soluble and have the ? half-life
soluble, shortest
synergistic (?), antagonistic (? effects), or permissive (one hormone ? the action of another)
together, opposing, amplifies/enabling
Hyposecretion of TH:
Hyposecretion of TH in adults
Can lead to ? also called ? thyroiditis
Symptoms of Myxedema include:
Low ? rate, Low BP, Low ?, Feeling chilled, Constipation, Mental sluggishness
If Hyposecretion of TH due to iodine deficiency in diet is called an ? Goiter
A goiter may develop and Thyroid gland enlarges
Hyposecretion in infants is called ? ? = Cretinism
Mother’s lack of iodine during gestation results in cretinism
myxedema, hashimotos, metabolic, HR, Endemic, Congenital Hyperthyroidism
Hypersecretion of TH:
Most common type of Hypersecretion of TH is ? disease an Autoimmune disease
Body makes abnormal ? that mimic TSH; abnormal antibodies stimulate thyroid gland to release TH at hyper elevated rates
Symptoms of Graves’ disease include
Elevated metabolic rate, Rapid heartbeats, Exophthalmos = eyes protrude
Thyroid Gland secretes Calcitonin in response to high Ca blood levels = Humoral response
Calcitonin stimulates osteoblast and Ca⁺ to move into the bone which ↓ Ca⁺ levels in
blood
? to parathyroid hormone (PTH)
Graves, antibodies, antagonist
functions of blood:
1. ?
2. ?
3. Protection
transportation, regulation
components of blood in a centrifuged blood sample are
55% plasma, 45% blood (erythrocytes), <1% formed elements (buffy coat)
pH of blood is
7.35-7.45
Blood is the Internal ? System
transport
The percentage of total blood volume occupied by erythrocytes is called the
hematocrit
blood is the only ? ? ? in the body
fluid connective tissue
Fluid Matrix is nonliving fluid called ?
plasma
Normal Hematocrit values: Males ~ ?% and Females ~ ?%
47, 42
? = too few RBCs; ? = too many RBCs
anemia, polycythemia
viscous means
sticky
blood is denser than
water
If RBC count is ? normal, then there is an ↑ viscosity ↓ blood flow ↑ risk of blood clots
IF RBC count is ? normal, then there is an ↓ viscosity ↑ blood flow ↓ risk of blood clots
above, below
Volume of Blood: Males ? L and Females? L
5-6, 4-5
Plasma protein, ?, produced in liver, makes up 60% of plasma proteins
albumin Functions as
1. Blood ?
2. Contributes to plasma osmotic pressure
albumin, buffer
characteristics of components of blood:
Only ? are complete cells that have nuclei
? have no nuclei or other organelles
? have no nuclei; are cell fragments of ?
WBC’s, RBC’s, platelets, megakaryocytes
Hemoglobin is a ?
protein
Structural Characteristics of Erythrocytes:
- no ?, allowing them to change shapes
- ? shape
- thin membrane
- contain ?
- their membrane is a ? bilayer
- have a cytoskeleton
nucleus, biconcave, hemoglobin, lipid
Function of Erythrocytes
RBCs transport respiratory ?
? binds reversibly with oxygen and carbon dioxide
gases, hemoglobin
hemoglobin is for ? transport, specifically ?
gas, oxygen
heme (a ? colored pigment in blood that contains ?) is responsible for the transportation of ? molecules and ? ? through the bloodstream
red, iron, oxygen, carbon dioxide
? is essential in making hemoglobin and transporting ?
iron, oxygen
globin’s primary function is to transport oxygen to the body’s ?
tissues
The primary function of oxygen in blood is to transport ? and make ?
oxygen, energy
RBC’s carry ? ? from tissues to the lungs for exhalation
carbon dioxide
? (ruby red)
? (dark red)
oxyhemoglobin, deoxyhemoglobin
? is a compound of carbon dioxide and hemoglobin that transports ? ? in the blood
carbaminohemoglobin, CO2
? is the blood cell production process
Hematopoiesis
Stem cells in the red bone marrow that give rise (secrete) to all formed elements are called ?
hemocytoblasts
Hormones and Growth Factors
1. RBC hormone = ?
2. WBC hormone = ? and CSF
3. Platelets hormone = ?
erythropoietin, interleukins, thrombopoietin
? is the process by which ?, also known as erythrocytes, are produced in the body
Balance is important because
1. Too few RBCs lead to ? (O₂ deprivation in TISSUES)
2. Too many RBCs ↑ blood viscosity ↓ Blood Flow ↑ risk of blood clots
Erythropoiesis, RBC’s, hypoxia
? stem cells are precursors to the other lines of blood cells: erythrocytes, ? (neutrophils, eosinophils, and basophils), monocytes, and ?
myeloid, granulocytes, platelets
? are ? red blood cells (RBCs) that are produced in the bone marrow and released into the bloodstream
reticulocytes, immature
Hormonal control = ? (EPO)
EPO stimulates formation of RBCs
hypoxia in kidney (liver) → EPO → ? Bone Marrow → to produce ?
erythropoietin, red, RBC’s
Dietary reqs for RBC production:
1
2
3
4
5
6
amino acid, b12, copper, C, folic acid, iron
Removal: ? in the spleen and liver remove old or ? RBCs from circulation.
Breakdown: The ? in the RBCs is broken down into heme and globin.
Recycling: The ? protein may be recycled or broken down into amino acids, which may also be recycled or metabolized
macrophages, damaged, hemoglobin, globin
? = Blood’s O₂ carrying capacity is too low to support normal metabolism
anemia
1.? Anemia = lack of EPO due to kidney failure
- ?-? anemia
Iron intake low or cannot absorb Iron in intestines. Cannot produce hemoglobin - ? anemia = lack of intrinsic factor (autoimmune disease of elderly)
Intrinsic factor needed to absorb B₁₂ in small intestines. B₁₂ needed to help RBCs multiply in red bone marrow. Treatment = B₁₂ injections - ? Anemia = too many RBCs destroyed
RBCs rupture or lyse prematurely
5.?-? anemia results from mutated hemoglobin protein called Hemoglobin S = HbS
renal, iron-deficiency, pernicious, hemolytic, sickle-cell
? is abnormal excess of rbc’s which leads to an ↑ blood viscosity ↓blood flow which causes ↑ risk of blood clotting
polycythemia
WBC’s:
characterized by their ability to move through tissue to reach ? sites, have a distinct ?, and are produced in the bone ?
infection, nucleus, marrow
leukocytes or WBCs Protect body from
?, ?, ?, Toxins, Tumor cells
bacteria, viruses, parasites
WBC’s from complex to simple:
?: Most abundant WBC, first responders to infection, fight bacteria and fungi.
?: Primarily responsible for viral defense, producing antibodies through B cells and direct cell killing through T cells.
?: “Garbage collectors” that engulf and digest debris and pathogens.
?: Primarily target parasites and allergic reactions.
?: Release histamine, contributing to allergic reactions.
neutrophils, lymphocytes, monocytes, eosinophil, basophil
- Granulocytes (Gregory never eats basil)
Contain visible ? granules and shorter-lived - Agranulocytes
Do not contain visible ? granules
Granulocytes
1. ?
2. ?
3. ?
Agranulocytes
1. ? = B cells and T cells
2. ?
cytoplasmic (2x), neutrophils, eosinophil, basophil, lymphocytes, monocytes
The body produces more WBC’s when it’s fighting an ? or ?
infection, illness
? is the process by which WBC’s move from the bloodstream through the walls of ? and into surrounding ?
Diapedesis, BV, tissues
? means you have a high white blood cell count
leukocytosis
? ? is the rapid release of the reactive oxygen species (bleach and hydrogen peroxide) from different cell types
respiratory burst
? is the production of WBC’s in bone marrow
Leukopoiesis
? are a group of proteins that regulate immune responses and play a key role in the body’s defense against ?, ?, and inflammation
Interleukins, infection, injury
?-? ? (CSFs) are a group of proteins that regulate the production of blood cells in the bone marrow
colony-stimulating factors
? (also known as thrombocytes) are tiny, cell-like fragments found in the blood that play a crucial role in ? ?
platelets, blood clotting
? are large, multinucleated cells found in the bone marrow that are responsible for producing platelets
Megakaryocytes
? (TPO) is the primary hormone that regulates ? production for blood clotting
thrombopoietin, platelet
? is a fast series of reactions to stop ? in BV wall breaks
hemostasis, bleeding
The ? pathway responds to spontaneous, internal damage of the vascular endothelium, whereas the ? pathway becomes activated secondary to external trauma.
Both meet at the common pathway to continue ?
intrinsic, extrinsic, coagulation
Platelets stay Mobile and Inactive by endothelial cell secretions
1. Platelets Remain Mobile by Nitric Oxide = causes ?
2. Platelets Remain Inactive by Prostacyclin = inhibits ? of platelets
vasodilation, agglutination
Serotonin released by platelets causes
vasoconstriction
? A2 induces platelet aggregation
Thromboxane
Clotting factors are procoagulants and are mostly plasma proteins in inactive form
1. Most clotting factors are made by ? and numbered I to XIII in order of discovery
2. Vitamin ? is a coenzyme needed to synthesize 4 clotting factors in liver
3. ? = cofactor
liver, K, calcium
Coagulation occurs in a cascade of reactions to
1. ? and ? pathway to Prothrombin activator
2. Prothrombin activator catalyzes ? to Thrombin
3. Thrombin catalyzes Fibrinogen to ?
intrinsic, extrinsic, prothrombin, fibrin
? ? is a process that occurs after a blood clot forms to stabilize the clot and promote wound healing
clot retraction
Platelet-derived growth factor (PDGF) is released during ? healing and ? formation
wound, BV