Test 1 Complement

Question 1

Is complement humoral or cell mediated?

Answer 1

Humoral

Question 2

Definition of complement

Answer 2

Series of proteins in the circulation that, when activated, act as enzymes and participate in a number of biologic activities, including lysis of cells, opsonization, chemotaxis, and so forth.

Question 3

Most susceptible cells to complement

Answer 3

WBCs, RBCs, platelets, gram neg bacteria

Question 4

Most resistant cells to complement

Answer 4

yeasts, fungi, gram pos bacteria, plant/animal cells

Question 5

Which immunoglobulins activate complement

Answer 5

IgG and IgM

Question 6

C1 is produced by

Answer 6

Macrophages of the intestine and peritoneum

Question 7

C3 produced by

Answer 7

liver, lymph nodes, bone marrow, gut, epithelial cells

Question 8

At what reaction do the two pathways converge?

Answer 8

C5 (membrane attack complex)

Question 9

The classic pathway begins with

Answer 9

C1qrs (activated by IgG or IgM)

Question 10

The alternate pathway begins with

Answer 10

C3, Factor B, Factor D, properdin

Question 11

Both patways end at

Answer 11

C9

Question 12

C5 is called the

Answer 12

membrane attack complex

Question 13

The alternate pathway does not use these reactions

Answer 13

C1, C4, and C2

Question 14

What is the end result of complement?

Answer 14

Cell lysis

Question 15

Cascade interaction of complement leads to

Answer 15

opsonization, immune adherance, and chemotactic and anaphylatoxic activity

Question 16

What are the 3 phases of complement?

Answer 16

Recognition phase
Activation phase
Attack phase