Terms Flashcards
ABO discrepancy
A difference in test results from the expected. Ex. forward grouping and reverse grouping do not match.
Anti-A1
(80% of A group) will react with A1 cells, but not with A2 cells
Dolichos biflorus
Plant extract that, when prepared, contains anti-A1 lectin (agglutinates RBCs containing A1 antigen)
Glycosyltransferase
Enzymes which act as a catalase for the transfer of a monosaccharide unit from an activated sugar phosphate to an acceptor molecule, usually an alcohol. They are involved in the formation of some blood group antigens.
Naturally Occuring
Occuring without known stimulus.
Reverse Grouping
seroligical test in which serum containing unknown ABO antibody(ies) is tested with red blood cells of known ABO group. For example, is a serum reacts with the A1 red blood cell, but not with the B red blood cell, it contains anti-A and does not contain anti-B (expected reactions of a group B person). (AKA serum grouping, confirmation grouping, back typing).
Type II chain
the glycolipid precursor chain found on the surface of RBCs
Acquired B
occurs in patients with intestinal blockages which allows E. coli through the intestinal wall into the bloodstream. Group A and group O people will aquire a B-like antigen to become AB or B people, with anti-B in their plasma.
Bombay
phenotype that results from lack of the H gene (i.e. the person is hh). Bombay people forward group as group O and reverse group as group O because of presence of a potent anti-H. Group O red blood cells, however, are highly incompatible with Bombay sera because of the anti-H.
Amorphic
silent gene; O gene in ABO is amorphic (it appears to have no genetic product or to produce no detectable product)
Cis-AB
Occurs because of unequal crossing over of genetic information due to genetic mutation.
Forward Grouping
test in which unknown RBCs are mixed with antisera of know specificity to determine presence or absence of antigens on the red blood cells. For example, in ABO forward grouping, red blood cells are tested with reagent anti-A and anti-B. Agglutination with the reagent indicates presence of the antigen; no agglutination indicates the absence (AKA front typing, cell typing, cell grouping, forward typing).
Issoagglutinins
ABO antibodies
Non-red cell stimulated
term used to describe red blood cell antibodies that are not formed through direct stimulation by a red blood cell antigen.
Secretor
a person who has inherited the Se gene in single or double dose. Such people secrete ABH substances in their body fluids.
