Rh Review Sheet Information Flashcards
Name the three sets of allelic genes in the Rh system:
Dd Cc Ee
What is the Fisher-Race theory of inheritance?
Antigens are produced by 3 closely liked sets of alleles
What is the Weiner theory of inheritance?
The Rh gene produces an agglutination that produces a series of blood factors (antigens). The Rh gene produces at least 3 factors per agglutination.
What is Tippetts theory of inheritance?
2 closely liked structural loci (D and CcEe) are produced. 1 allele at the first loci (D) and 4 and the second (Ce, CE, cE, ce). The action is dependent on the RHAG gene.
What are the five common antisera used for typing the antigens in the Rh system?
anti-D anti-C anti-E anti-c anti-e
What causes genetic weak D?
D antigens are complete, but few in number (most frequent in African Americans, rare in Caucasians)
What is causes C trans?
Caused by gene interaction effect. The allele carrying the D antigen is in the opposite haplotyp to the allele carrying the C antigen (Dce/dCe). The arrangement of the C antigen in relationship to the D antigen appears to interfer with the expression of the D antigen.
What causes partial D (aka mosaic D)?
One or more parts of the D antigen are missing. It types weaker than expected or not at all. It may form anti-D to the missing parts of the D antigen. Once anti-D had been identified, the patient must be transfused with D neg blood.
What are the symptoms of the Rh null phenotype?
RBC membrane abnormalities Mild compensated hemolytic anemia Reticulocytosis Slight decrease in H&H Increase Hgb F Stomatocytosis
Rh mod symptoms are similar to _______ but are (less/more) sever. It results from _____
Rh null, less sever, weakened antigen expression
Which antibody classes are Rh antibodies?
Mostly IgG (some IgM)
How are Rh antibodies stimulated?
though transfusion or pregnancy
Can HDFN or HTR be caused by Rh antibodies?
Yes
Do Rh antibodies bind complement?
No
Do Rh antibodies cross the placenta?
Yes
