Term 1- Lec 6- Membrane Transport Flashcards

1
Q

What type of molecules pass the cell membrane via simple diffusion?

A

Small, non-polar (hydrophobic) molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the two types of membrane proteins that mediate transport?

A

Channel and Carrier proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Another name for Passive Diffusion

A

Facilitated Diffusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Passive transport

A

Does not require energy and the molecules move down their concentration/electrochemical gradients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Direction of molecules in Active Transport

A

Against their respective gradients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

T/F: Uncharged molecule transport is determined by their concentraion and electrochemical gradients

A

FALSE; Uncharged molecules do not have a charge therefore an uneffected by electrochemical gradients.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The types of active transport and their differences

A
  • 1º active transport: Uses ATP as it’s E source

* 2º active transport: Uses E from an electrochemical gradient.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

T/F: Channel proteins bind to thier solutes

A

False; their solutes pass through them as long as their open.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Acetylcholine-gated ion channels

A

Located in muscle cells, when acetylcholin binds to the channel, the gate opens and Na+ enters the cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Uniport Carriers

A

A single molecule moves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Symport Carriers

A

Simultaneous transport of 2 different molecules. A form of Coupled Transport

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antiport Carriers

A

Transport of two different molecules in opposite directions. aka “Exchangers”. A form of Coupled Transport

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The GLUT protein family proteins are what type of __-port carrier

A

They are all Uniporters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The GLUT protein family proteins exhibit what kind of transport

A

Passive Transport—Carrier Proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Low Km = what affinity

A

High affinity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

High Km = what affinity

A

Low affinity

17
Q

Location of GLUT1

A

Brain, Erythrocyte, placenta, fetal tissue

18
Q

Location of GLUT2

A

Liver, Kidney, Intestine, Pacreatic ß-cells

19
Q

Location of GLUT3

A

Brain

20
Q

Location of GLUT4

A

Muscle, adipose tissue.

21
Q

Km of GLUT1

A

High affinity/ Low Km- allows for constant uptake

22
Q

Km of GLUT2

A

Low affinity/ High Km

23
Q

Km of GLUT3

A

High affinity/ Low Km- allows for constant uptake

24
Q

Km of GLUT4

A

Intermediate affinity (insulin regulated). They are recruited to cell surface by insulin signal

25
Q

What is unique about GLUT4 compared to the rest of it’s protein family?

A

GLUT4 is not always present on it’s cell’s surfaces. It is insulin-regulated. It is in vesicles awaiting an insulin signal to bring it to the surface.

26
Q

Tight Junctions do what two things in epithelial cells?

A
  1. Establish directionallity in cells

2. Prevent apical proteins from migrating to basolateral locations (establishing direction)

27
Q

Glucose transport between adjacent cells

A

Paracellular Transport

28
Q

Glucose transport in via apical membrane and out via basolateral membrane

A

Transcellular Transport

29
Q

What are the three membrane proteins used in Glucose transport from lumen to bloodstream? What type of transport are they?

A

Apical: Na-Glucose Transporter—2º active transport—Symport
Basolateral: Na/K ATPase—1º active transport—Antiport & GLUT2—Passive transport—Uniport

30
Q

Movement of Na+ at apical surface

A

2 Na+ move Into the enterocyte ALONG it’s gradient. E used to move Glucose into enterocyte

31
Q

Movement of Na+ at basolateral membrane

A

3 Na+ move out of the enterocyte AGAINST it’s gradient. Uses ATP to maintain Na+ gradient.

32
Q

Movement of K+ and where does this occur

A

Basolateral membrane. 2 K+ moves into the enterocyte.