Teratogens Flashcards
1
Q
Renal failure, Oligohydramnios?
A
- ACE inhibitors
- ARBs
2
Q
Otoxicity
A
aminoglycosides
3
Q
Cartilage damage
A
Fluoroquinolones
4
Q
Discolored teeth
A
Tetracyclines
5
Q
- Ear/facial anomalies
- Limb hypoplasia
- Absence of digits
A
Cyclophosphamide
6
Q
-Neural tube defects
A
- Methotrexate
- Carbamazepine
- Valproic acid
7
Q
Fetal hydantoin syndrome
A
Phenytoin
8
Q
Ebstein anomaly
A
Lithium
9
Q
CNS and limb abnormalities
A
-Statin
10
Q
- Bone/cartilage defects
- Nasal hypoplasia
A
Warfarin
11
Q
- spontaneous abortion
- birth defects
A
Isotretinoin
12
Q
Clear cell vaginal adenocarcinoma
A
Diethylstilbestrol (DES)
13
Q
Phocomelia
A
thalidomide
14
Q
- CNS malformations (early exposure)
- Malignancy (late exposure)
A
Ionizing Radiation
15
Q
- Spontaneous abortion
- microcephaly
- cardiac defects
- Can interfere with neural crest cell migration or HOX gene expression
A
Excess Vitamin A
16
Q
- Cardiac Defects
- Neural tube defects
- Caudal regression syndrome
A
Maternal Diabetes
17
Q
Congenital hypothyroidism (cretinism)
A
Maternal iodine deficiency
18
Q
- Placental Abruption
- Low birth weight
- IUGR
A
- nicotine
- cocaine
19
Q
- Facial abnormalities (narrow eye openings, wide-set eyes, smooth philtrum, thin upper lip, cleft palate)
- Intellectual disability
- microcephaly
- holoprosencephaly
A
Fetal alcohol syndrome
