Tenofovir

Question 1

Tenofovir

Answer 1

Pharmacologic Class: NRTI’s

Therapeutic Class: Antiretroviral

Question 2

Action

Answer 2

Inhibits activity of HIV-1 reverse transcriptase and HBV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’ triphosphate.

Incorporation into the DNA by DNA chain termination.

Question 3

Use

Answer 3

To treat HIV-1 infection.

To treat chronic HBV (Hep-B)

Question 4

Complications

Answer 4

Acute Hepatitis

Pancreatitis

Angioedema

Hypokalemia

Lactic Acidosis

Question 5

Contrindication/Precaution

Answer 5

Hypersensitive to tenofovir or its components.

Question 6

Interactions

Answer 6

Atazanavir

Didanosine

High Dose or multiple NSAID

Aminoglycosides

Question 7

Client Education

Answer 7

Take as prescribed, if missed dose take ASAP but do not double dose, do not stop taking without consult with provider.

Bone density scanning may be ordered

S/S of infection

Avoid NSAID use

Do not breastfeed if HIV and during therapy

Increase intake of Vitamin D and Calcium

Question 8

Dose

Answer 8

300mg/day must weight 77lbs