Enfuvirtide

Question 1

Enfuvirtide

Answer 1

Pharmacologic Class: Fusion Inhibitor

Therapeutic Class: Antiretroviral

INJECTION (SUBQ)

Question 2

Action

Answer 2

Interferes with entry of HIV-1 into cells to inhibit fusion of cellular membrane with the virus.

Binds to the viral envelope glycoprotein and preventing the conformational changes required for fusion.

Question 3

Use

Answer 3

To treat HIV-1 infection in treatment experienced patients w/ HIV-1 replication despite ongoing therapy.

Question 4

Complications

Answer 4

Gullian-Barre Syndrome

Suicidal Ideations

Hypotension

Hepatitis

Renal Failure

Sepsis

Hypersensitive Reaction

Question 5

Contraindications/Precautions

Answer 5

Hypersensitive to Enfuvirtide or its components.

Question 6

Interactions

Answer 6

None reported by manufacturer

Question 7

Client Education

Answer 7

Will be used in conjunction with other antiretroviral agents.

How to use a needle and give themselves SUBQ injections.

Rotate injection sites in abdomen, front of thigh, and upper arm.

How to store medication (refrigerator, used within 25hrs).

S/S of infection at injection site.

Question 8

Dose

Answer 8

90mg/TID SUBQ