Fenofibrate

Question 1

Fenofibrate

Answer 1

Pharmacologic Class: Fibrate

Therapeutic Class: Antilipemic

Question 2

Action

Answer 2

Increase hepatic elimination of cholesterol as bile salts

Decrease synthesis of fatty acids and triglycerides.

Promotes the catabolism of larger, less dense LDL with a high-binding affinity for cellular LDL receptors.

Question 3

Use

Answer 3

Treat and prevent hypercholesterolemia and hyperlipidemia

Question 4

Complications

Answer 4

DVT

Cirrhosis

Steven-Johnson Syndrome

Hepatitis

Acute renal failure

PE

Thrombocytopenia

Angioedema

Question 5

Contraindications/Precautions

Answer 5

Gallbladder disease

Hypersensitive

Severe hepatic impairment

Unexplained persistent elevated liver enzymes

Biliary cirrhosis

Severe renal impairment

Question 6

Interactions

Answer 6

Bile acid sequestrates

Colchicine

Immunosuppressants

All food

Coumarin Anticoagulants

Question 7

Client Education

Answer 7

Follow provider instructions about diet and exercise

Swallow whole

Protect drug from moisture and light

Follow up with labs

Tell provider about unexplained muscle pain, tenderness, weakness.

Monitor urine, stool, skin for changes in color.

Wear sunscreen

Question 8

Dose

Answer 8

150mg/day