TEMPERATURE AND PAIN 2

Question 1

The triple response occurs as a result of

injury (e.g., wound) and is characterized by the following three conditions:

Answer 1

reddening, wheal and flare.

Question 2

In addition to being an activator, bradykinin acts as a ___________ and increased permeability of capillary membranes.

Answer 2

vasodilator (leading to heat and redness)

Question 3

Around the inflamed area, there is a pink-colored zone known as a ________-

Answer 3

flare.

Question 4

Leads to fluid accumulation and swelling (edema, also known as a wheal).

Answer 4

BK vasodilator

Question 5

Bradykinin activates ____________,

leading to depolarization and generation of action potentials.

Answer 5

C fiber nociceptors

Question 6

___________ produces vasodilation but typically to a lesser extent than does bradykinin

Answer 6

Substance P

milder vasodilation produces the pink color of the flare

Question 7

Substance P is a classic example of a sensitizer and will reduce the threshold for activation of nociceptors with collaterals in the exposed region.

Thus, nociceptors with _______ within the pink flare will be activated more easily

Answer 7

peripheral processes

Question 8

Modality segregation allows different second-order cells to process simultaneously information associated with each sensory modality.

Answer 8

Afferents conveying information of different sensory modalities reach the CNS in an organized manner and segregate to different regions of the dorsal horn (known as laminae).