TD: ODT Technology

Question 1

How to recogonize ODT Technology

READ

Answer 1

Question 2

What is the european requirment fo ODT

Answer 2

Orodispersible tablets disintegrate within 3 mins when examined by the test for disintegration……. Oral lyophilisates disintegrate within 3 mins when added to 200ml of purified water at 15 to 25°C

Question 3

Why use ODT in terms of:

• Formulation
• Clinical
• Marketing

Answer 3

Question 4

What is the process by which Zydis ODT is made - this is responsible for the rapid disintigration of zydis - What time do they disintigrate in?

Describe this process in greater depth

Answer 4

• ~3s

Process:

1. Form solution or suspension
2. Pour into blister pack
3. Freeze
4. Freeze dry to remove water:
   
   • Sublimes water (L—>G). Degree of supercooling effects nucleation and growth.
5. Remove and will quickly disperse (water moves through pores)

Question 5

What excipients make up Zydis?

Answer 5