IPP: Contraceptive methods Flashcards
How does the COC work and what is examples?
Primarily inhibits ovulation:
- Progesterone and Oestrogen act on the hypothalamus pituitary axis to inhibit release of FSH and LH.
- No surge of LH and FSH to stimulate the ovaries so ovulation does not occur.
- Also effects cervical mucus and endometrium:
- Progesterone causes thickening of cervical mucus preventing sperm entry and prevents hyperplasia of the endometrium by opposing the proliferative effects of oestrogen
- The oestrogen component of the CC causes the endometrium to proliferate and grow.
What is the effectiveness of the COC
- Use: 92%
- Theoretical: 99.7%
What are the advantages of the COC
- Makes period lighter, shorter and pain-free
- Reduces risk of 3 types of cancer by 50%
- More effective than barrier methods
- Sexual intercourse doesn’t need to be interrupted
- Reduced acne in some women
- Normal fertility returns immediately after stopping
- Reduce risk of benign breast disease, osteoporosis, corectal cancer and of functional ovarian cysts and benign ovarian tumours
- Reliable and reversible
Disadvantages of COC
- Replies on patient remembering to take them
- Doesn’t protect against STIs – use condom too.
- Less effective than Long-acting reversible methods
- Some women experience temporary adverse effects when they start COCs (nausea, abdo pain, headache, breast-tenderness and mensutational irreg)
- Only used in certain groups of women
Legal Framework for supply for COCs
How does the POP work?
Examples?
- Aka mini-pill: Levonorgestrel, Desogestrel, norethisterone
5 independent mechanisms of action:
- Suppression of ovulation
- Suppression of mid-cycle peaks of LH and FSH
- Production of ‘hostile, blocked’ mucus resulting in poor sperm penetration
- Reduction in the number and size of endometrial glands and inhabitation of progesterone receptor synthesis in the endometrium, preventing implantation.
- Reduction in the activity of cilia in the Fallopian tube
Effectiveness of the POP
- Use: 92%
- Theoretical: 99.7%
Advantages of POP
- More effective than barrier methods (when correctly taken)
- Sex not interrupted
- Used when COC not suitable
- Reduce risk of endometrial cancer
- Normal fertility returns when POP stopped
- Desogestrel may be beneficial in managing dysmenorrhoea.
Disadvantages of POP
- Replies on patient remembering to take them
- Pills must be taken at the same time each day, or within 3 hours, except for the desogestrel-only pill, which must be taken within 12 hours to be effective.
- Doesn’t protect against STIs – use condom too.
- Temporary adverse effects when start POPs (unscheduled bleeding, breast tenderness)
- Only used in certain groups of women
Legal framework for POPs
How does the contraceptive patch work?
Example?
Ortho Evra contraceptive patch
Same mechanism as POP:
5 independent mechanisms of action:
- Suppression of ovulation
- Suppression of mid-cycle peaks of LH and FSH
- Production of ‘hostile, blocked’ mucus resulting in poor sperm penetration
- Reduction in the number and size of endometrial glands and inhabitation of progesterone receptor synthesis in the endometrium, preventing implantation.
- Reduction in the activity of cilia in the Fallopian tube
Effectiveness of the progesterone patch?
- Use: 92%
- Theoretical: 99.7%
Advantages of the patch?
- Applied weekly so more convenient that pill everyday
- Patches do not become less effective if vomit or diarrhoea
- Patch as effective as COCs
- Doesnt interupt sex
Disadvantages of the patch
- It can be seen
- Can become partially or completely detached compromising efficacy
- Less effective if >90kg
- Risks and adverse effects e.g. skin irritation, nausea, vomiting and unscheduled bleeding
- Delay in returning to normal fertility after stopping – up to few months
- Doesn’t protect against STIs
Legal framework for the patch
How does the progesterone only injection work?
How often is it given?
Examples
Depot medroxyprogesterone acetate (Depo Provera® and Sayana Press®) or norethisterone enantate (Noristerat®)
- Given once every 3 months
- Inhibit ovulation and thicken cervical mucus, therby presenting a barrier for sperm pentetration.
- Also changes endometrium environment making it unfavourable to sperm.
Effectiveness of the progesterone only injection?
- Use: 97%
- Theoretical: 99.5%
Advantages of the progesterone only injection?
- Can make periods disappear all together
- It is very effective
- Users do not have to think about contraception for as long as the injection lasts — 12 weeks for DMPA and 8 weeks for NET-EN.
- Sex not interrupted
- Used when breastfeeding
- No known interactions with medicine
- Can reduce heacy periods with premenstrual symptoms
- Used where COCs not recommended
- Still used if BMI >35kg/m2
- Reduce risk of ovarian and endometrial cancer
Disadvantages of progesterone only injection?
- It is not rapidly reversible. After stopping use of progestogen-only injectables: There could be a delay of up to 1 year in the return of normal fertility.
- Menstruation can take several months to return to normal.
- Doesn’t protect from STIs
- Adverse effects including unscheduled bleeding and weight changes may occur.
Legal Framework for progesterone injection
How does the implant work?
Examples?
What is it?
- Nexplanon (etonogestrel)
- 4cm tube filled with progesterone inserted sub dermally into the upper arm.
- Once removed immediately use another contraceptive to avoid getting pregnant
- Works by inhibiting ovulation and also causes change in cervical mucus that inhibits sperm entry
Effectivness of the implant?
- Use: >99%
- Theoretical: >99%