TCA cycle Flashcards
1
Q
Essential vitamins needed for PDH & a-KG DH?
A
B1 (thiamine)
Lipoic acid
2
Q
Activators of PDH?
A
ADP
Pyruvate
3
Q
Inhibitors of PDH
A
Acetyl CoA
NADH
Ca2+ from muscle activity
4
Q
What is the major point of regulation of the TCA cycle?
A
Isocitrate DH
Activated by Ca2+ & ADP
5
Q
What is the vitamin needed for anaplerotic reactions?
A
Biotin
Co-factor for pyruvate carboxylase
6
Q
Activator of pyruvate carboxylase?
A
Acetyl-CoA
7
Q
What is the main inhibitor of the TCA cycle?
A
NADH
8
Q
What enzyme is inhibited in mercury/arsenic poisoning?
A
PDH
a-KG DH
Inhibits lipoic acid which is needed by the 2 enzymes
