Glycogen metab

Question 1

What is the enzyme regulated during glycogen synthesis?

Answer 1

Glycogen synthase

Question 2

What is the enzyme regulated during glycogen degradation?

Answer 2

Glycogen phosphorylase

Question 3

Where is G-6-Phosphatase located in?

Answer 3

ER in liver and kidney tissues (gluconeogenic tissues)

Question 4

Activators of glycogen phosphorylase?

Answer 4

Glucagon
AMP
Ca2+

Ca2+ complexes with calmodulin which activates phosphorylase kinase –> phosphorylates glycogen phosphorylase

Question 5

3 inhibitors of Glycogen phosphorylase?

Answer 5

ATP
G-6-Phosphate
Glucose

Question 6

Activators of glycogen synthase?

Answer 6

Glucose-6-phosphate
Insulin

Question 7

Hormonal effects of insulin?

Answer 7

Dephosphorylation of:

Glycogen synthase to active form
Glycogen phosphorylase to inactive form

Question 8

Hormonal effect of glucagon?

Answer 8

Phosphoryation of:

Phosphorylase kinase –> activates glycogen phosphorylase
Glycogen synthase to inactive form

Question 9

What are the 6 glycogen storage diseases?

Answer 9

Von Gierke
Pompe
Cori
Anderson
McArdle
Her’s

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