Gluconeogenesis

Question 1

What are the 3 irreversible steps in glycolysis that need to be overcome?

Answer 1

Pyruvate –> PEP
F-1,6-P2 –> F6P
G6P –> Glucose

Question 2

Co-factor for pyruvate carboxylase?

Answer 2

Biotin
Acetyl CoA activates the enzyme

Question 3

Major point of regulation for gluconeogenesis?

Answer 3

F-1,6-P2 –> F6P

Question 4

Activators of fructose-1,6-biphosphatase?

Answer 4

ATP
Citrate

Same as PFK1 inhibitors in glycolysis

Question 5

Inhibitors of fructose-1,6-biphosphatase?

Answer 5

AMP
F-2,6-P2

Same as PFK1 activators in glycolysis

Question 6

Inhibitor of Pyruvate –> PEP?

Answer 6

ADP