TCA cycle

Question 1

where does the TCA cycle occur?

Answer 1

mitochondria

Question 2

is the TCA cycle aerobic or anaerobic?

Answer 2

Aerobic

Question 3

what are the 5 coenzymes of pyruvate dehydrogenase and the alpha-ketoglutarate dehydrogenase complex ?

Answer 3

NAD+
FAD
Coenzyme A
LIpoic acid
Thiamine pyrophosphate (TPP)

Question 4

what are the activators of pyruvate dehydrogenase?

Answer 4

pyruvate
NAD+
ADP
Ca2+
CoA

Question 5

What are the deactivators of pyruvate dehydrogenase?

Answer 5

acetyl CoA
NADH
ATP

Question 6

what are the activators of isocitrate dehydrogenase?

Answer 6

ADP

Ca2+

Question 7

what are the inhibitors of isocitrate dehydrogenase?

Answer 7

ATP

NADH

Question 8

what are the activators for alpha-ketoglutarate dehydrogenase?

Answer 8

Ca2+

Question 9

what are the deactivators for alpha-ketoglutarate?

Answer 9

NADH

Succinyl- CoA

Question 10

how many ATP are generated from 1 acetyl CoA per TCA cycle?

Answer 10

12

Question 11

what is the total amount of energy (ATP) that theoretically can be gained from 1 molecule of glucose that cycles through the body?

Answer 11

38 ATP

Question 12

what are the 2 key enzymes in TCA that are inhibited in arsenic poisoning?

Answer 12

PDH

alpha-ketoglutarate dehydrogenase

Question 13

what is Wernicke- Korsakoff syndrome?

Answer 13

encephalopathy psychosis caused by a deficiency in thiamine

Question 14

what population is Wernicke-Korsakoff often seen in ?

Answer 14

chronic alcoholics

Question 15

what deficiency can cause Leigh syndrome?

Answer 15

PDH

Question 16

what are the symptoms of Leigh syndrome?

Answer 16

chronic lactic acidosis 
neurodegeneration
muscle spasticity
early death
brain damage