Gluconeogenesis

Question 1

what are the 2 organs that perform gluconeogenesis?

Answer 1

Liver (mostly)

kidney (prolonged fast)

Question 2

glycerol is released from hydrolysis of TAGs and converted into what?

Answer 2

DHAP

Question 3

What is the cori cycle?

Answer 3

glucose to lactate through anaerobic glycolysis
to the liver
lactate converted back to glucose
released back to circulation

Question 4

amino acids (specifically Alanine) for gluconeogenesis are derived from what source?

Answer 4

hydrolysis of muscle proteins

Question 5

Acetyl CoA can be converted into pyruvate in humans. T or F?

Answer 5

FALSE

Question 6

what regulator found in both glycolysis and gluconeogenesis has opposite effects and keeps the pathways exclusive?

Answer 6

fructose 2-6-BP

Question 7

How does glucagon affect fructose 2,6-BP?

Answer 7

inhibits PFK-2
lowers fructose 2,6-BP
activates gluconeogenesis

Question 8

how does glucagon affect PEP?

Answer 8

inhibits pyruvate kinase

PEP is used for gluconeogenesis instead of glycolysis

Question 9

how do glucagon and insulin affect PEPCK?

Answer 9

insulin- inhibits

glucagon- stimulates

Question 10

where does the energy for gluconeogenesis come from?

Answer 10

oxidation of fatty acids in the liver

Question 11

what does a build up of acetyl CoA signal to pyruvate carboxylase?

Answer 11

OAA is being diverted for gluconeogenesis, not TCA cycle