TCA Flashcards
0
Q
Malonate
A
Analogue (3-C) of succinate; competitive inhibitor of Succinate Dehydrogenase, inhibition causes block of TCA cycle; build up of succinate, citrate, and alpha-ketoglutarate
1
Q
Fluoroacetate
A
Suicide inhibition of Aconitase; fluorine binds to Fe2+
2
Q
Trivalent arsenic aka Arsenite
A
inhibits enzymes with lipoic acid enzymes as cofactor, i.e.alpha-KGDH, PDH
