ETC

Question 0

Amytal

Answer 0

Complex I inhibitor

Question 1

Rotenone

Answer 1

Complex I inhibitor

Question 2

Piericidan A

Answer 2

Complex I inhibitor

Question 3

Antimycin A

Answer 3

Complex III inhibitor

Question 4

CN

Answer 4

Complex IV inhibitor

Question 5

Azide

Answer 5

Complex IV inhibitor

Question 6

CO

Answer 6

Complex IV inhibitor

Question 7

HS

Answer 7

Complex IV inhibitor

Question 8

2,4-Dinitrophenol

Answer 8

Uncoupler; dissipates proton gradient by binding H+ in intermembrane space and moving to matrix

Question 9

Valinomycin

Answer 9

Uncoupler; Antibiotic that makes inner membrane permeable to K+; pH gradient still intact

Question 10

Gramicidin A

Answer 10

Uncoupler; channel forming drug

Question 11

UCP (brown fat)

Answer 11

Uncoupler; UCP1 (thermogenin) in Brown Fat produces non-shivering thermogenesis

Question 12

Atractyloside

Answer 12

Depletion of intramitochondrial stocks of ADP; shut down of ATP synthesis; failure to dissipate proton gradient resulting in ETC shut down; located in intermembrane space

Question 13

Acid Bongkrekic (mold toxin)

Answer 13

inhibits Adenine Nucleotide Translocase (ANT); prevents ATP from leaving mitochondria; Located in inner membrane space;