Enzymes

Question 1

HMG CoA Reductase

Answer 1

Feedback genetic inhibition

makes cholesterol

Question 2

Diisopropylfluorophosphate (DFP)

Answer 2

OH - hydroxyl group of Serine

Acetylcholinesterase inhibitor (Irreversible inhibition); more acetylcholine 
Also ingredient in organic phosphate insecticides (farmers)

Question 3

Iodoacetate

Answer 3

Acts at sulphydryl, imidazole, carboxyl, thioester groups
Alkylating agent on Thiol groups, cys residues

(Irreversible inhibition)

Potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase @ sulfhydryl group (in Glycolysis)

Question 4

Disulfiram

Answer 4

aka antabuse

alcoholism aversion therapy

Aldehyde dehydrogenase (Irreversible inhibition

treats: alcoholism relapse

Question 5

Aspirin

acetylsalicylic acid

Answer 5

inhibits COX-1&2 via acetylation
(Irreversible inhibition);
Ser530 lies on wall of tunnel; Acetylation of Ser blocks tunnel so arachidonic acid can’t go to active site

Question 6

Statin

Answer 6

Competes with HMG-CoA for the active site of HMG-CoA Reductase, which makes cholesterol

treats: Hyperlipidemia

Question 7

Azidothymidine

Answer 7

Viral reverse transcriptase (competitive inhibitor) not human dna polymerases

Question 8

Allopurinol

Answer 8

Xanthine oxidase (suicide inhibitor aka irreversible inhibitor); Rx for Gout

Question 9

Captopril

Answer 9

Inhibits ACE angiotensin-converting enzyme,
decreased plasma angiotensin II (vasocontrictor)
-vasodilation occurs
BP decreases

treats: hypertension