TBL 11. Flashcards
catalase
coaguolase: Staphylococcus aureus
staphylokinase:
Staphylococcus aureus: capsule (not always)
protein A: Staphylococcus aureus
hemolysins:
panton-valentine leucocidin: Staphylococcus aureus
TOXIN
LEADS TO LEUKOPENIA
enterotoxins A-E:
toxic shock synderome toxin ( TSST-1) : Staphylococcus aureus
what type of infections are caused by Staphylococcus aureus?
hair follicle infections?
describe the Pyogenic infection of Staphylococcus aureus with virulence factor coagulase.
CRITICAL IN ABSCESS FORMATION
describe the Pyogenic infection of Staphylococcus aureus with virulence factor TSST-1.
describe the Pyogenic infection of Staphylococcus aureus with virulence factor protein A.
characteristics of describe Staphylococcus aureus
what are the Staphylococcus aureus
Host Immune Elements?
Neisseria species characterics
transmission
what are the pathogenic species we care about ?
N. meningitidis causes meningococcemia and meningitis.
N. gonorrhoeae transmits sexually, infects urethra in men and the cervix in women,
Neisseria species
Host Immune Functions
what receptors do neutrophils use against Neisseria species?
CD14, TLR2, TLR4, FcR, CRs.
what are the virulance factors of Neisseria species?
Ig A protease
capsule (different form other type)
what is effective against their capsule?
pili: Neisseria species
How does it avoid the immune system?
Neisseria species : cell wall lipooligosaccharide
can cause_____
porin A, Porin B, Opa, Opc: Neisseria species
iron sequestration: Neisseria species
describe meningococcal meningitis vs. meningococcemia (what factor leads to this)
what causes it?
meningococcemia, usually in immuno deficient.
waterhouse-frederinchsen syndrome: damage to adrenal gland blood vessels
describe how virulence factors, Ig A protease, capsule, porin A, porin B, opa, Opc, pili, iron sequestration, LOS are able to evade the immune system? in Neisseria species
what leads to purpura and petechae?
Mycobacterium tuberculosis characteristics
they have ______ and _______like (neisseria species)
what are the common strains in the USA
transmission
risk factors
M.leprae
Kansasii
avium
how does immune system defend itself against Mycobacterium tuberculosis ? who is more at risk for this infection?
virulance factors of Mycobacterium tuberculosis ?
mycolic acid: Mycobacterium tuberculosis
cord factor: Mycobacterium tuberculosis
Mycobacterium tuberculosis: sulfatides
block phagolosome formation
Mycobacterium tuberculosis: ESX 1 secretion
system
survive in phagosome
superoxide dismutase: Mycobacterium tuberculosis:
protect from oxidative killing
Mycobacterium tuberculosis: catalase
what other bacteria has catalase?
protect from oxidative killing
s. aureus
Mycobacterium tuberculosis: infections
symptoms of TB
M.leprae causes: _____
reactivation of Mycobacterium tuberculosis: is called _______
describe the pathogenesis of Mycobacterium tuberculosis.