TBL 10 Flashcards
Antibody-mediated disorders (type II)
Immediate hypersensitivity (type I)
Immune complex-mediated disorders (type III)
Cell-mediated immune disorders (type IV)
CD4 is the major cell
48 -72 hours after exposure
major players of type 1?
mast cell, eosinophil, basophil, igE
first vs subsequent exposure to antigen in type 1
2, receptors are already found to mast cell, so crosslinking occurs
where are mast cells found ?
which portion of the Fc epsilon receptor I has carried the binding site for IgE? and which one is for signaling ?
what are the 3 responses of mast cells to secondary exposure in type 1?
CROSSLINKING OCCURS
PROPERTIES OF MAST CELLS, BASOPHILS, AND EOSINOPHILS
response created with parasites
what determines if Th0 will become a Th2?
genes invloved in type 1
IgE-MEDIATED ALLERGIC REACTIONS CONSIST OF AN IMMEDIATE
RESPONSE FOLLOWED BY A LATE-PHASE RESPONSE
Mediators Released During Immediate and Late Phase
Immediate mediators: histamine
late response:
cytokines, chemokines, lipid mediators
histamine effects
ALLERGIC RHINITIS/HAY FEVER
what are the mechanisms of antibody meadiated diseases?
what are the mechanisms of antibody meadiated diseases?
Type II clinical examples?
drugs that cause these reactions
if mistch of blood happens, what will happen?
ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY
(ADCC), what cells are able to do this?
and what types of molecules do they use?
MENN are toxic
when to give RhoGAM
direct coombs test is used to test which type of hypersensitive and when is it used?
Type II
indirect combs test
ANTIBODY-MEDIATED/ TYPE II HYPERSENSITIVITY-MEDIATED
AUTOIMMUNE DISEASES
Drug-induced Anemia or Thrombocytopenia
Most common:______________
type_____reaction
how do we remove it from the system?
Penicillin-Induced Type II Response
what is rheumatic fever?
why does rheumatic fever occur and what other tissues are involved?
symptoms to rheumatic fever?
how to diagnose rheumatic fever?
type III antigens and what kind of problems will they cause
type III categories of immune complex diseases?
mechanism of poststreptococcal glomerulonephritis ?
TYPE III: IMMUNE COMPLEX-MEDIATED HYPERSENSITIVITY dieseases
Polyarteritis nodosa (PAN) is a rare type of vasculitis that causes inflammation of the medium-sized arteries.
when will the body not be able to clear the type III complexes
explain mechanism of the basis of immune reaction of type III?
serum sickness disease is an example of ?? how does it work?
symptoms associated with it
type III
it is systemic
route of antigen entering body in type III and resulting disease?
arthus reaction mechanism? and what type of hypersensitivity is it?
what kind of cell binds to AB and which recpetor?
does not happen immediately
type III, dont confuse with one, It is mast cell, but Fc Gamma receptors bound to IgG
does not happen immediately (within minutes)
notice TIME
T CELL-MEDIATED HYPERSENSITIVITY diseases
Delayed Type IV Hypersensitivity (DTH)
SYSTEMIC ANAPHYLAXIS
common causes?
EARLY AND LATE PHASE
RESPONSE IN ALLERGIC
ASTHMA
Penicillin-Induced Systemic Anaphylaxis (type I)
Penicillin-Induced Systemic Anaphylaxis mechanism
HYPERSENSITIVITY TYPE IV characteristics
requirement for T CELL-MEDIATED DELAYED HYPERSENSITIVITY
DELAYED TYPE HYPERSENSITIVITY (DTH) and examples. Primary and secondary mediators
Delayed-Type Hypersensitivity mechanism
INTRACELLULAR PATHOGENS & CONTACT ANTIGENS
THAT INDUCE DTH (DELAYED TYPE HYPERSENSITIVITY)
The Type IV response is designed to eliminate parasites and ________
Problems arise when the response is prolonged as a result of failure to eliminate the pathogen.
contact dermatitis
