TBI Models

Question 1

controlled cortical impact injury model

Answer 1

Mimics concussion, axonal injury, BBB dysfunction

Easily reproducible

Question 2

Marmaraow’s weight drop model

Answer 2

Mimics generalised concussion

Metal disk over skull prevents bone fractures from weight drop

Question 3

Shohami’s weight drop model

Answer 3

Used for focal injury

Weight drop delivered to one side of unprotected skull

Question 4

Fluid Percussion Injury

Answer 4

Mimics clincial TBI without skull fracture

Presents brain swelling and intracranial heamorrhage (subdural injury)

Question 5

Blast Injury Model

Answer 5

Investigate black waves affecting brain, inducing diffuse injuries (military TBIs without external injuries)