Fibrosis Models Flashcards
1
Q
Bleomycin
A
clinically relevant - causes pf in humans
inflammation is key (not in humans)
reversible, self limiting (not progressive)
Cheap, many studied at once
2
Q
Transgenic - Virus
A
Viral vector introduced
Understand pathogenesis and gene products
Promotes vigorous immune response
3
Q
Transgenic - Pulmonary
A
Does not mimic pf in humans
Controls gene expression
4
Q
FITC
A
Intra-tracheal Destroys lung architecture and induces pf Allows visualization of with IF imaging Persistent and not self-limiting Expensive
5
Q
Irradiation
A
Single dose of whole body irradiation
Lengthy and expensive
Characterized differences between mice strains
6
Q
Silica
A
Fibrotic nodules
Occupational exposure in humans
Non-replicable exposure
Lengthy and expensive
7
Q
Name 6 experimental models of pulmonary fibrosis
A
Bleomycin Transgenic - virus and pulmonary Silica FITC Irradiation
