TBC (pathoma ir UW) 12/12 Flashcards
4 drugs for TBC treatment?
RIPE:
Rifampin
Isoniazid
Pyrazinamide
Ethambutol
Rifampin mechanism?
Inhibition of bacterial DNA-dependent RNA polimerase -> halts bacterial proteins synthesis
Inhibition of bacterial DNA-dependent RNA polimerase.
Drug?
Rifampin
Rifampin. 4 side effects?
GI, rash, red-orange body fliuds, cytopenias
GI side effect?
Rifampin.
Rash side effect?
Rifampin.
red-orange body fliuds?
Rifampin.
Cytopenias?
Rifampin.
Isoniazid mechanism?
Inhibition of mycolic acid synthesis
Inhibition of mycolic acid synthesis?
Isoniazid
Isoniazid side effect?
Neurotoxicity (give vitB6/pyridoxine) -> peripheral neuropathy, therefore with drug give simultaneously pyridoxine
hepatotoxicity -> during first 4-6 months of treatment
Neurotoxicity (give vitB6/pyridoxine)?
Isoniazid
Hepatotoxicity (2)?
Isoniazid, Pyrazinamide
Pyrazinamide mechanism?
Unclear
Pyrazinamide side effects?
Hepatotoxicity, hyperuricemia
hyperuricemia?
Pyrazinamide
Ethambutol mechanism?
Inhibition of arabinosyl transferase
Inhibition of arabinosyl transferase?
Ethambutol