TB MEDS

Question 1

What therapy is given for active TB?

Answer 1

Triple antibiotic therapy

Question 2

TB: Isoniazid (INH, Hydrazide, PDP- Isoniazid)

Answer 2

Kills growing bacteria and inhibits growth of dormant bacteria

Take on empty stomach (prevent slowing of drug absorption in GI)

Take multivitamin

Do not drink alcohol - liver damage

Report dark urine, yellow skin, white eyes, bruise/bleed (liver toxicity or failure)

Question 3

TB: Rifampin (RIF, Rifadin, Rimactane, Rofact)

Answer 3

Kills slow growing organisms

Orange/red stain of skin and urine
Contact lenses stained

Reduces BC

No alcohol - liver damage

Dark urine, yellow skin, white eyes, bruise/bleed (liver toxicity)

Interacts with many drugs

Question 4

TB: Pyrazinamide (PZA)

Answer 4

Kill organisms in acidic environment

Increases uric acid, Makes gout worse

8oz water - prevent uric acid

Photosensitivty (sun)

No alcohol - liver damage

Dark urine, yellow skin, white eyes, bruise/bleed (liver toxicity)

Question 5

TB: Ethambutol (EMB, Etibi, Myambutol)

Answer 5

Inhibits RNA synthesis, suppress bacterial growth

Slow acting and bacteriostatic (use w other anti TB drugs)

Changes in vision (optic neuritis) blindness

No alcohol - nausea and vomit

Increase uric acid - worse gout

8 oz water - prevent uric acid