PD & HD MEDS

Question 1

What does treatment focus on for PD?

Answer 1

Increase Dopamine, Decrease Acetylcholine

Question 2

PD: Dopaminergics include?

Answer 2

Levodopa and Carbadopa (Sinemet)

Question 3

PD: Levodopa is converted into what?

Answer 3

Dopamine

Question 4

PD: Carbidopa is combined with Levodopa for what effect?

Answer 4

To decrease the breakdown of Levodopa

Question 5

PD: Dopamine agonists include what?
What do they do?
What can they cause?

Answer 5

Pramipexole (Mirapex) and Ropinirole (Requip)
Activate release of Dopamine
Orthostatic hypotension, drowsiness, dyskinesias and hallucinations

Question 6

PD: Anticholinergics include what?

Answer 6

Trihexyphenidyl (Artane) and Benztropine (Cogentin)

Question 7

PD: What do anticholinergics treat?
What do they cause?

Answer 7

Tremors
Dry mouth, constipation, urinary retention, acute confusion

Question 8

PD: Catechol-O-methyltransferase (COMT) inhibitors include what?
What are the side effects?

Answer 8

Entacapone (Comtan)
Taken with Levodopa
Decreases breakdown of levodopa
Dark urine

Question 9

PD: Monoamine oxidase type B (MAO-B) inhibitors include what?
What are the side effects?

Answer 9

Selegiline
Taken with levodopa
Increases dopamine
Helps with wearing off effect of levodopa
Avoid foods with Tyramine!

Question 10

PD: Antivirals include what? What does it do?

Answer 10

Amantadine, stimulates the release of dopamine and prevent reuptake

Question 11

HD: Tetrabenazine (Xenazone)

Answer 11

Suppress involuntary chorea movements
Side effects include: depression, nausea, restlessness, suicide