Targeted Therapies Flashcards

1
Q

SERMs

A

Tamoxifen
Competitive inhibitor of estradiol
Antagonist effects in breast cancer
Estrogenic effects on non breast tissues
Inc risk of thromboembolic events with age

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2
Q

Aromatase inhibitors

A

Anastrazole
Block the fxn of aromatase (converts androgens to estrogens)
Lower incidence of AE than Tamoxifen

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3
Q

Estrogen and feedback inhibition

A

Leoprolide acetate

Initially LH/FSH rise, until they turn off from constant GnRH stimulation

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4
Q

-mab

A

Monoclonal Ab

Infusion rxns, HTN, heart failure common with males

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5
Q

BCR-ABL

A

Imatinib
Inhibits BCR-ABL
Promotes fluid retention

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6
Q

EGFR

A

Erlotinib
Inhibits EGFR
Blocks enzymatic fxn of EGFR through competitive blockade
Pustular/popular rash
Cetuximab
Binds specifically to extracellular domain of EGFR

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7
Q

Trastusumab

A

HER2/neu inhibitor
Binds to external domain of HER2
SE: cardiac failure

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8
Q

VEGF

A
Class effects: potential for vessel injury in bleeding
Bevacizumab
Ab directed against VEGF-A
Risk of bleeding and poor wound healing
Thalidomide
Withdrawn due to teratogenic effects
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9
Q

Bortezamib

A

Inhibitor of proteasome-mediated protein degradation, induce arrest at G2-M phase and apoptosis
NEUROPATHY

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10
Q

Rapamycins

A

mTOR inhibitors

Temsirolimus

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