Non-Cell Cycle Specific

Question 1

Alkylation agents

Answer 1

Cytotoxic effects related to alkylation of reactive amines, oxygens, or phosphates on DNA
Acute effects manifests against rapidly proliferating tissues
AE: carcinogenic in nature (inc risk of 2 malignancies), vesicants, toxic effects on make and female repro

Question 2

Nitrogen mustards

Answer 2

Cyclophosphamide, Ifosfamide
Beware of water intoxication from adequate hydration
Urothelial damage
Severe hemorrhagic cystitis
Metabolized by CYP450
Mesna conjugated acrolein in urine

Question 3

Busulfan

Answer 3

Alkyl sulfonates
Causes pulmonary fibrosis
Leukocyte count may cont to drop for a month after discontinuation

Question 4

Platinum analogs

Answer 4

Cisplatin, Carboplatin
Oto and nephrotoxic
Not cross resistant with oxaliplatin

Question 5

Doxorubicin

Answer 5

Abx
Irreversible cardiomyopathy
Generates free radicals
Metabolized in the liver
Cardiotoxicity:
Acute- two to three days arrythmias occur and conduction abnormalities
Chronic- dose dependent dilated cardiomyopathy associated with heart failure