Eicosanoids And NSAIDs

Question 1

Systemic prostaglandins cause:

Answer 1

CRAMPING AND DIARRHEA

Question 2

PGI2

Answer 2

Inhibition of platelet aggregation

TXA2 is a potent vasoconstrictor and platelet aggregator, must balance between the two

Question 3

Latanoprost, Travaprost, Bimatoprost

Answer 3

PGF2a analogs
Resistant cases of open angle glaucoma
Itchy red painful eyes, changes eye color

Question 4

Lipooxygenase pathway

Answer 4

Blocking cyclooxygenase will inc production of leukotrienes and block production of prostaglandins
Leukotrienes will cause bronchoconstriction (Asthmatics!!!)

Question 5

COX 1 v 2 inhibition

Answer 5

Cox 1: antiaggregation

Cox 2: (inhibiting PGI2 formation) proaggregation, vasoconstriction

Question 6

Aspirin

Answer 6

Irreversible acetylates cyclooxygenase
Anti inflammatory, antipyretic, analgesia, antiaggregation
Irreversibly inhibits cox in platelets (bronchospasm)
Salicylism: tinnitus and wide anion gap acidosis

Question 7

Aspirin and NSAIDs

Answer 7

SE
Cox1: GI bleed, antiplatelet, thrombosis
Cox2: THROMBOSIS
Cox2 Selective NSAIDs are cardiotoxic

Question 8

Acetaminophen

Answer 8

No resp or renal effects
Toxicity: chronic alcoholism induces CYP450 2E1 and can deplete glutathione stores (malnutrition)
N-Acetylcysteine is antidote for toxicity