tablets (exam 3) Flashcards
tablets have _______________ as compared to solutions
slower absorption
solubility can be an issue for tablets due to
absorption
bioavailability
__________ is the key driver in the delivery route
dose
as the dose increases,
drug delivery options become more limited
tablet formation
die filling
compression
tablet formation
tablet ejection
die filling
delivery of powder into a mold –> compression of the blend into a tablet
tablet press
device that compresses powder into tablets
types of tablet presses
single punch
rotary press
computerized hydraulic press
output of tablets of single punch
rotary press?
200 tabs/min
1000 tabs/min
powder properties to be controlled
uniformity
flowability
compression and compactability
friction and adhesion of powders
types of tablets
conventional
chewable
buccal
sublingual
effervescent
modified release, sustained release
which tablet forms cannot be split?
modified release formulations
compressed tablet subtypes
compressed uncoated tablets
suger-coated tablets
film-coated tablets
enteric coated tablets
compression coated tablets - SR
multiply compressed tablets
what is a multiple compressed tablet
separate incompatible ingredients and/or sustained release
excipients examples
fillers (diluents)
binders
lubricants/glidants
disintegrants
fillers (diluents)
increase bulkiness of tablet
binders
“glue” everything together
lubricants/glidants
ease ejection of tablet from die
disintegrants
cause the tablet to disintegrate in an aqueous environment
insoluble fillers
calcium sulfate - dihydrate
calcium phosphate - di/tribasic
calcium carbonate
starch
modified starches
microcrystalline cellulose
soluble fillers
lactose
sucrose
dextrose
mannitol
sorbitol
binders examples
sugers
natural polymers (starch, gums)
synthetic polymers (methyl and ethylcellulose, povidone)
lubricants prevent sticking of tablets to _________ and prevents _________
punches
excessive wear on punches and dies
example of lubricants
metal stearates
example of disintegrants
starch
gelatin
cellulose derivatives
calcium silicate
on contact with water, disintegrants
swell, hydrate, change in volume or form to produce a disruptive change in the tablet
common tableting methods
wet granulation
dry granulation
direct compression
common tablet tests
weight uniformity
content uniformity
tablet hardness
friability
disintegration
dissolution
general comparison of tablet hardness
SL and buccal > oral tablets > chewable tablets
when weighing tablets under 650 mg,
use enough to weigh more than 6.5 grams
when weighing tablets over 650 mg,
weigh ten tablets
determine friability which is
less than 1% loss
complete disintegration
state in which the unit is a soft mass without a firm core
three disintegrations can occur
crystals
soft heterogenous granules w/ excipients and drug
hard granules and impermeable
tablets must meet the stated monograph requirement for
rate of disintegration and dissolution
in vitro dissolution test
predict bioavailability
quality control for manufacturing
requirement for regulatory approval
