Granules Flashcards
granules
prepared agglomerates of smaller particles of powder
size and shape of granules
4-12 sieve
irregular or spherical shaped
how to prepare granules?
wet method
dry method
basic wet method
moisten the powder
pass the paste through a screen of mesh
dry the granules by air/heat on drying trays
fluid bed method
place particles in conical equipment
spray liquid excipient on vigorously dispersed and suspended particles
dry
dry granulation method
light compaction of powder material
compacted powder broken to granules
dry granulation method is commonly used for materials that are
moisture sensitive
administration of granules
measured and mixed with water
sprinkled on food
eaten plain
effervescent granules and tablets should be
dissolved in water before use
effervescent granules provide
pleasant vehicle for bitter/salty drugs
effervescent granules composition
medicinal agent
sodium bicarbonate
citric acid and tartaric acid
granules or coarse particles decrease the rate of
solution and prevent uncontrollable effervescence