Tablet Dosage Forms Lecture

Question 1

Tablet

Answer 1

Solid dosage forms

Medicinal substances with suitable pharmaceutical ingredients or excipients

Question 2

Advantages of tablets

Answer 2

Precision and accuracy
Mask bitter taste
Simple and portable
Stable
Convenience
Complicance is higher
Less expensive

Question 3

Disadvantages of tablets

Answer 3

Powders and granules are not always compressible
Not extemporaneously
Difficult to swallow
Infexible if not scored

Question 4

Conventional compressed tablets

Answer 4

Single compression cycle
Active ingredients and excipients
Uncoated tablets but can be coated after compression

Question 5

Multi-layered compressed tabelts

Answer 5

Two or more layers

• Dispense incompatible drugs
• Drug release in different stages
• Look good
• Color coded

Question 6

Sugar coated tablets

Answer 6

Several thin layers of color or uncolored sugared

• Protect against degradation
• Mask taste or smell
• Prevent unwanted contact with the drug
• Enhance appearance and elegance

Question 7

Film coated tablets

Answer 7

Thin layer of either water soluble or water insoluble polymer that ruptures in the GIT
More durable, less bulky, less time consuming
- Protects against degradation
- Alters dissolution profiles
- Reduces expenses, quickens process

Question 8

Enteric coated tablets

Answer 8

Pass unchanged from the stomach to the intestines
Polymers resist dissolution and disruption in the stomach
- Only dissolve at a pH 5-7

Question 9

Why enteric coated?

Answer 9

Prevent excess irritation in GIT
Prevent inactivation by gastric juice
Delay drug release
Deliver the active to optimum location

Question 10

Chewable tablets

Answer 10

Not swallowed
Disintegrate in saliva
Mannitol: sweetener
- Enhance palatability
- Children and adults unable to swallow

Question 11

Buccal tablets

Answer 11

Systemic action
Dissolve slowly
Between cheek and gum

Question 12

Sublingual tablets

Answer 12

Beneath tongue

Dissolve rapidly

Question 13

Why buccal or sublingual?

Answer 13

Protect drugs destroyed or inactivated in stomach
Deliver drugs that are not absorbed GIT
Avoid first pass
- Straight in oral mucosa

Question 14

Lozenges or troches

Answer 14

Dissolve slowly in the mouth for continuous local application
- Antiseptics, local anesthetics, antibiotics, and antihistamines

Question 15

Dental Cones

Answer 15

Prevent microbial growth

NOT ORAL

Question 16

Effervescent tablets

Answer 16

Release CO2 in contact with water

• Increase dissolution rate
• Enhanced palatability

Question 17

Tablet triturates

Answer 17

Molded or slightly compressed
Water soluble
Not hard

Question 18

Hypodermic tablets

Answer 18

Dissolve in a vehicle for injection

Question 19

Implants and pellets

Answer 19

Compressed drugs
Sterile
Inserted via surgery 
- Slow absorption
- Control release
- Greater use in vet meds

Question 20

Zoladex

Answer 20

Endometriosis or carcinoma

Question 21

Norplant

Answer 21

Contraceptive

Subq in the upper arm

Question 22

Vaginal Tablets

Answer 22

Uncoated bullet-shaped or ovoid tablets
Local effect
Prepared by compression
Disintegrate in the vaginal fluid

Question 23

Controlled release tablets and pellets

Answer 23

Oral
Release over long period
Decrease the frequency of admin
Sustain level for desired number of hours

Question 24

Instantly Disintegrating Tablets

Answer 24

10 seconds - 1 minutes
RDT: 15-30 seconds
Good for folk who can’t swallow

Question 25

Gelatin coated tablets

Answer 25

Capsule shaped tablets coated with gelatin (called caplets)

Question 26

Lyophilized tablets

Answer 26

Foaming a mixture of gelatin, sugar and drug