Tablet Composition Lecture Flashcards
Desired characteristics of a tablet
Characteristic color and shape
Bioavailable
Uniform in weight, thickness, and content
Strong and resistant
Ingredients in a tablet
One or more drugs
One or more non-therapeutic agent (additive excepients)
Absorbable drug
systemic effects
Non-Absorbable
Local effect in GIT
Diluents
Added to active ingredients to make a reasonably sized tablets
- Influence: hardness, disintegration, dissolution, biopharmaceutics, compressional force
Examples of diluents
Microcrystalline cellulose
Calcium phosphate
Sugar tab, Di-pac, Nu-tab (for compressible and chewable tablets)
Binders
Add cohesiveness to powders
Facilitate bonding of particles to form granules
Natural gums and starches: acacia, gelatin, starch
Synthetic cellulose derivatives: HPMC
Disintegrating agent
Facilitate breakup of a tablet after admin
Facilitate sorption of water by binder
Promote rapid entry of water
- Starch, celluloses
Lubricants
Reduce friction at interface of tablet and die wall
Anti-adherent and glidant properties
- Adversely effect the drug release
- Increase insolubility = slower release, dissolution and disintegration
Water soluble lubes
Effervescent tablets
Sodium acetate, lauryl sulfate
Water insoluble lubes
More efficient
Stearates of magnesium, calcium, and sodium + stearic acid
Anti-adherents/Glidants
Prevent sticking to the punch and die wall
Improve flow
Minimize seperation
Colors
Tablet DI, cosmetics, differentiate strengths
Dyes
Produce color
Water soluble
Lakes
FD&C water soluble dyes
Water insoluble dyes
