Tables Combined Flashcards
What urologic imaging procedures have no radiation exposure?
Ultrasound, MRI.
Hint: Imagine the sound of the ocean and the mysterious magnetic resonance of the earth – all natural, no radiation!
What are the examples of urologic imaging procedures with minimal radiation exposure (less than 0.1 mSv)?
Chest radiographs.
What are the examples of urologic imaging procedures with low radiation exposure (0.1-1.0 mSv)?
Lumbar spine radiographs, pelvic radiographs.
What are the examples of urologic imaging procedures with medium radiation exposure (1-10 mSv)?
Abdomen CT without contrast, nuclear medicine, bone scan, 99mTc-DMSA renal scan, IVP, retrograde pyelograms, KUB, chest CT with contrast.
What are the examples of urologic imaging procedures with high radiation exposure (10-100 mSv)?
Abdomen CT without and with contrast, whole-body PET.
What are mild allergic-like reactions to contrast medium?
Limited urticaria/pruritus, edema, throat irritation, nasal congestion, sneezing, eye irritation, rhinorrhea.
Hint: Think of a mild allergy to a garden flower – a little itch, a sneeze, but nothing a breeze can’t ease!
What are mild physiologic reactions to contrast medium?
Limited nausea/emesis, transient flushing/warm/chills, headache/dizziness/anxiety/altered taste, mild hypertension, vasovagal but resolves spontaneously.
Hint: A mild case of seasickness – a little nausea, a bit flushed, but you’ll soon be back to tasting the salty air!
What are moderate allergic-like reactions to contrast medium?
Diffuse urticaria/pruritus, erythema, facial edema, throat tightness, mild wheezing/bronchospasm.
Hint: A touch of sunburn at the beach – more than a tingle but less than a blaze!
What are moderate physiologic reactions to contrast medium?
Protracted nausea/emesis, hypertension, chest pain, vasovagal responds to treatment.
Hint: Like a bumpy boat ride – you might need a hand to steady yourself, but you won’t capsize!
What are severe allergic-like reactions to contrast medium?
Diffuse edema/facial edema/shortness of breath, erythema, hypotension, laryngeal edema with hypoxia, wheezing/bronchospasm with hypoxia, anaphylactic shock/hypotension/tachycardia.
Hint: A storm on the horizon – dark and threatening, where calm seas turn to chaos!
What are severe physiologic reactions to contrast medium?
vasovagal reaction resists treatment, arrhythmia, seizures, hypertensive emergency.
Hint: A wild tempest at sea – resisting all efforts to quell, where waves crash and winds howl!
What does 18F-FDG target, and what is its effect?
Targets glucose transporters and hexokinases; affects aerobic and anaerobic glycolysis, glucose consumption.
Hint: Like a metabolic engine, 18F-FDG fuels both aerobic and anaerobic pathways, driving glucose consumption.
What do 11C-choline and 18F-choline target, and what is their effect?
Target choline kinase; impact cell membrane metabolism, tumor proliferation.
Hint: The building blocks of a cell’s shield, these choline markers reveal the hidden growth of tumors.
What does 11C-acetate target, and what is its effect?
Targets tricarboxylic acid cycle and fatty acid synthase; affects lipid synthesis.
Hint: In the intricate dance of cellular energy, 11C-acetate highlights the synthesis of fats, the storage of life’s fuel.
What does 18F-FDHT target, and what is its effect?
Targets androgen receptor; measures androgen receptor.
Hint: A sentinel for male hormones, 18F-FDHT stands guard, monitoring the gates of androgen communication.
What does 18F-NaF target, and what is its effect?
Targets hydroxyl and bicarbonate ions of bone hydroxyapatite; measures bone status.
Hint: As a geological surveyor maps the land, 18F-NaF explores the terrain of the bone, assessing its integrity.
What does 18F-FMISO target, and what is its effect?
Measures hypoxia; tumor hypoxia.
Hint: A silent witness to the suffocation of cells, 18F-FMISO uncovers the hidden distress within tumors.
What does 18F-FLT target, and what is its effect?
Targets thymidine kinase; nucleic acid synthesis, tumor proliferation.
Hint: A detective in the world of DNA, 18F-FLT traces the threads of life, unveiling the secrets of growth.
What does 18F-FACBC target, and what is its effect?
Affects neutral A–A type amino acid uptake and protein synthesis; protein synthesis.
Hint: A scholar of cellular language, 18F-FACBC deciphers the code of protein synthesis, the words that build life.
What does 68Ga-PSMA target, and what is its effect?
Targets prostate cell surface protein; tumor aggressiveness, androgen independence.
Hint: A warrior against prostate malignancy, 68Ga-PSMA faces the foe, revealing its strength and autonomy.
What are the characteristics of adrenal metastasis?
Variable size/shape; Heterogeneous when larger; >10 HU; RPW < 40; High T2 signal; Positive on PET images.
Hint: Unpredictable like a storm’s path, the features of adrenal metastasis shift and change, leaving traces in imaging like footprints in the sand.
What are the characteristics of adrenal cortical carcinoma?
> 4 cm; Variable shape/texture; >10 HU; RPW < 40; Intermediate to high T2 signal; Positive on PET images.
Hint: A dark shadow on the horizon, adrenal cortical carcinoma looms large and variable, its presence echoing in PET images like distant thunder.
What are the characteristics of pheochromocytoma?
Variable size/shape/texture; >10 HU rarely <10; RPW < 40; High T2 signal; Positive on MIbG.
Hint: A chameleon in the adrenal landscape, pheochromocytoma adapts and varies, revealing itself through high T2 signals like a hidden oasis.
What are the characteristics of a cyst in the adrenal gland?
Variable size; Smooth, round; Smooth texture; <10 HU; does not enhance; High T2 signal; Negative on PET.
Hint: A tranquil pond amidst the complexity, the cyst stands smooth and round, its serenity captured in high T2 signals like reflections on still water.
What are the characteristics of adenoma?
1–4 cm; Smooth, round; Homogeneous; <10 HU in 70%; RPW > 40; APW > 60; SI dropoff on OP images; Variable on PET images.
Hint: A benign sentinel, adenoma stands smooth and round, its higher RPW like a beacon of normality amidst complexity.
What are the characteristics of myelolipoma?
1–5 cm; Smooth, round; Variable with macroscopic fat; <0, often <-50 HU; No data on washout; High T1 signal, India ink, variable SI dropoff on OP images; Negative on PET images.
Hint: An enigmatic blend of bone marrow and fat, myelolipoma’s high T1 signal illuminates its unique nature like a lighthouse on a foggy shore.
What are the characteristics of lymphoma in the adrenal gland?
Variable size/shape/texture; >10 HU; RPW < 40; Intermediate SI; Variable positivity on PET images.
Hint: A shifting shadow, lymphoma’s variable features and lower RPW reveal a complex landscape, like clouds moving across a twilight sky.
What are the characteristics of hematoma?
Variable size; Smooth; Variable texture; >10, sometimes >50 HU; No data on washout; Variable signal; Negative on PET.
Hint: A mark of injury, hematoma’s variable nature and strong CT attenuation bear witness to trauma’s aftermath like scars on a battlefield.
What are the characteristics of neuroblastoma?
Variable size/shape; Smooth, round; >10 HU; RPW < 40; Variable if necrotic; Positive on PET.
Hint: A hidden storm within the nervous tissue, neuroblastoma’s smooth, round shape conceals a turbulent interior, like calm waters hiding a whirlpool.
What are the characteristics of ganglioneuroma?
Variable size/shape/texture; >10 HU; No data on washout; Usually intermediate SI; Usually negative on PET.
Hint: An elusive entity, ganglioneuroma’s variable features and intermediate SI paint a picture of uncertainty, like fog obscuring a distant mountain.
What are the characteristics of hemangioma?
Variable size/shape/texture; >10 HU; No data on washout; Usually intermediate SI; Usually negative on PET.
Hint: A vascular labyrinth, hemangioma’s complex features guide the way through a maze of blood vessels, like rivers winding through a dense forest.
What are the characteristics of granulomatous lesions?
1–5 cm; Smooth; Usually Homogeneous; >10 HU; No data on washout; Usually intermediate SI; Positive on PET images if active.
Hint: A chronic inflammation’s mark, granulomatous lesions stand smooth and usually homogeneous, their nature revealed in PET images like echoes of a distant fire.
What are the MRI characteristics of clear cell carcinoma in the kidney?
230% Corticomedullary, 250% Nephrogenic, 227% Excretory phase; 1698 ADC; High signal intensity heterogeneous on T2-weighted images.
Hint: Think of the clarity of a crystal, reflecting light intensely, mirroring the high percentage changes and heterogeneous high signal of clear cell carcinoma.
What are the MRI characteristics of papillary carcinoma in the kidney?
9% Corticomedullary, 92% Nephrogenic, 88% Excretory phase; 884 ADC; Low signal intensity homogeneous on T2-weighted images.
Hint: A low-profile mountain range, papillary carcinoma stands in contrast to the surrounding landscape with its low signals, like hidden valleys in the shadows.
What are the MRI characteristics of chromophobe carcinoma in the kidney?
98% Corticomedullary, 183% Nephrogenic, 159% Excretory phase; 1135 ADC; High T2-weighted signal intensity for central scar.
Hint: A scar from a past battle, chromophobe carcinoma bears its mark with pride, its high T2-weighted signal like a badge of honor.
What are the MRI characteristics of oncocytoma in the kidney?
208% Corticomedullary, 265% Nephrogenic, 237% Excretory phase; High T2-weighted signal intensity for central scar. A mirror image of chromophobe’s scar, oncocytoma’s central scar shines brightly on T2-weighted images, like a lighthouse guiding the way.
What are the MRI characteristics of angiomyolipoma in the kidney?
353% Corticomedullary, 285% Nephrogenic, 222% Excretory phase; Variable on T2-weighted images.
Hint: A river’s unpredictable flow, angiomyolipoma’s variable signal charts a course through twists and turns, like water shaping the landscape.
What is the ADC value for normal renal parenchyma?
2303
×
1
0
−
6
mm
2
/
s
×10
−6
mm
2
/s.
Hint: The fertile ground of the kidney, renal parenchyma’s high ADC value is the lifeblood of renal function, like a rich soil nurturing growth.
What are the MRI characteristics of transitional cell carcinoma (TCC) in the kidney?
ADC <450; High signal on T2-weighted images.
Hint: A bridge between forms, TCC’s high signal and low ADC value span the gap between benign and malignant, like a bridge over turbulent waters.
What does a PIRADS v2 score of “1 Very Low” signify?
It indicates that clinically significant prostate disease is highly unlikely to be present.
What PIRADS v2 category should be assigned if clinically significant prostate disease is equivocal?
A score of “3 Intermediate” should be assigned.
If a patient’s MRI indicates a “5 Very High” PIRADS v2 score, what does it mean?
It means that clinically significant prostate disease is highly likely to be present.
If an MRI shows a “2 Low” score in PIRADS v2, what does it indicate?
A “2 Low” score indicates that clinically significant prostate disease is unlikely to be present.
What PIRADS v2 category corresponds to a scenario where clinically significant prostate disease is likely?
A score of “4 High” corresponds to a scenario where clinically significant prostate disease is likely to be present.
Arrange the PIRADS v2 categories in ascending order of likelihood for the presence of clinically significant prostate disease.
Arrange the PIRADS v2 categories in ascending order of likelihood for the presence of clinically significant prostate disease.
Arrange the PIRADS v2 categories in ascending order of likelihood for the presence of clinically significant prostate disease.
The PIRADS v2 scoring system is used to interpret and report prostate MRI findings, predicting the likelihood of clinically significant prostate cancer, and guiding further clinical decisions.
What is the density and impedance of fat tissue in urologic ultrasound?
Density: 952 kg/m³, Impedance: 1.38 kg/m²s.
Which tissue has the highest impedance in urologic ultrasound?
Bone and other calcified objects have the highest impedance at 7.80 kg/m²s.
How do the density and impedance of liver and kidney compare?
Both have similar density (1060 kg/m³), but the liver has slightly higher impedance (1.64 kg/m²s) compared to the kidney (1.63 kg/m²s).
What is the significance of density and impedance in urologic ultrasound?
Density and impedance affect how ultrasound waves travel through tissues, influencing the reflection and transmission of the waves. They are essential for imaging and diagnosing various urologic conditions.
Arrange the tissues from the lowest to highest impedance encountered in urologic ultrasound.
Air and other gases (0.0004)
Fat tissue (1.38)
Water and other clear liquids (1.48)
Kidney (1.63)
Liver (1.64)
Muscle (1.70)
Bone and other calcified objects (7.80)
What is the half-life of
67
Ga
67
Ga, and what are its positron energy levels?
67
Ga
67
Ga has a half-life of 78.3 hours. Positron energy levels: 93 keV (37%), 185 keV (20%), 300 keV (17%), 395 keV (5%).
What is the positron energy of
99
�
Tc
99m
Tc, and what percentage is it emitted at?
:
99
�
Tc
99m
Tc has a positron energy of 140 keV, emitted at 89%.
Which radionuclide has the shortest half-life among
67
Ga
67
Ga,
111
In
111
In, and
99
�
Tc
99m
Tc?
9m
Tc has the shortest half-life of 6.0 hours.
List the radionuclides according to their half-lives, starting from the longest.
67
Ga: 78.3 hours
111
In
111
In: 67.3 hours
99
�
Tc
99m
Tc: 6.0 hours
What are the applications of single-photon emitting radionuclides in medical imaging?
They are used in nuclear medicine for procedures like SPECT (Single Photon Emission Computed Tomography) to visualize and diagnose various medical conditions, including cancer, heart disease, and neurological disorders.
What is the half-life, positron energy, and range in soft tissue of
11
C
11
C?
Half-life: 20.3 minutes, Positron energy: 960 keV, Range in soft tissue: 3.9 mm.
Which radionuclide has the longest range in soft tissue, and how is it produced?
68
Ga has the longest range in soft tissue (8.9 mm) and is produced by a generator.
List the radionuclides by their half-lives, starting from the shortest.
11
C: 20.3 minutes
18
F
18
F: 109.8 minutes
68
Ga
68
Ga: 68.0 minutes
89
Zr
89
Zr: 78.4 hours
124
I
124
I: 4.17 days
What are the positron energy levels and corresponding ranges in soft tissue for
124
I
124
I?
Positron energy: 1525 keV (50%) and 2138 keV (50%), Ranges in soft tissue: 6.9 mm and 10.2 mm.
What are the applications of positron-emitting radionuclides in medical imaging?
They are used in PET (Positron Emission Tomography) imaging to visualize metabolic processes, diagnose and stage cancer, evaluate heart conditions, and assess neurological disorders.
What is the mechanism of uptake for Na
18
F
18
F, and what is its approved indication?
Na
18
F
18
F exchanges with hydroxyl groups on hydroxyapatite at areas of bone turnover. Approved for imaging bone to define areas of altered osteogenic activity.
Which radiotracer is a glucose analogue used for assessing abnormal glucose metabolism in cancer patients?
18
F-FDG.
What is the approved indication for
11
C
11
C-choline?
Imaging of men with suspected prostate cancer recurrence and noninformative bone scintigraphy, CT, or MRI.
Name a radiotracer used for prostate cancer imaging that is not FDA approved.
68
Ga
68
Ga-PSMA-11,
18
F
18
F-DCFPyL, or
68
Ga
68
Ga-RM2.
What is the mechanism of uptake for
18
F
18
F-FACBC, and what is its approved indication?
:
18
F
18
F-FACBC is an amino acid analogue taken up by metabolically active cells undergoing protein synthesis. Approved for imaging men with suspected prostate cancer recurrence based on elevated PSA levels.
What defines a Complete Response (CR) for target lesions in RECIST criteria?
Disappearance of all target lesions, and any pathologic lymph nodes must have a reduction in the short axis to <10 mm.
What percentage decrease in the sum of diameters of target lesions qualifies for a Partial Response (PR)?
At least a 30% decrease in the sum of diameters of target lesions.
What defines Progressive Disease (PD) for nontarget lesions in RECIST criteria?
Unequivocal progression of existing nontarget lesions and/or the appearance of new lesions.
What is Stable Disease (SD) in the evaluation of target lesions?
Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD.
What is the criteria for Complete Response (CR) in nontarget lesions?
Disappearance of all nontarget lesions, all lymph nodes must be <10 mm in size, and normalization of any tumor marker levels.
What characterizes Grade 1 in the CTCAE system?
Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not required.
What does Grade 2 indicate in the CTCAE system?
Moderate symptoms; minimal, local, or noninvasive intervention indicated; limiting age-appropriate instrumental ADLs.
Describe the severity and intervention needed for Grade 3 in the CTCAE system.
Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADLs.
What are the consequences and intervention required for Grade 4 in the CTCAE system?
Life-threatening consequences; urgent intervention indicated.
What does Grade 5 represent in the CTCAE system?
Death.
What defines Grade I in the Clavien-Dindo Classification?
Minor deviations without intervention. Example: Prolonged postoperative ileus. Hint: Think of “Initial discomfort.”
What characterizes Grade II in this classification?
Deviations requiring pharmacologic treatment beyond Grade I. Example: Bleeding after nephrectomy needing transfusion. Hint: “Intervention with meds.”
Describe Grade IIIa in the Clavien-Dindo Classification.
Needing intervention WITHOUT general anesthesia. Example: Drain placement with local anesthesia. Hint: “IIIa = Anesthesia Avoided.”
What defines Grade IIIb in this classification?
Needing intervention WITH general anesthesia. Example: Unplanned return to the operating room. Hint: “IIIb = Bring on Anesthesia.”
What characterizes Grade IVa in the Clavien-Dindo Classification?
Life-threatening, single-organ dysfunction; ICU needed. Example: Isolated myocardial infarction. Hint: “IVa = Individual Organ Crisis.”
Describe Grade IVb in this classification.
Life-threatening, multi-organ dysfunction; ICU needed. Example: Myocardial infarction leading to multi-organ failure. Hint: “IVb = Battle with Multiple Organs.”
What defines Grade V in the Clavien-Dindo Classification?
Death of a patient. Example: Postoperative mortality. Hint: Grade V is the “Finality.”
What KPS and ECOG scores represent a normal, fully active individual?
KPS: 100, ECOG: 0. The individual is fully active and able to carry out all pre-disease performance without restriction.
What do KPS 60 and ECOG 2 indicate about a patient’s abilities?
The patient requires occasional assistance but is able to care for most of their own needs. They are ambulatory but unable to carry out work activities.
What is the status of a patient with KPS 10 and ECOG 4?
The patient is moribund, completely disabled, cannot carry out self-care, and is totally confined to bed or chair.
What is the International Prostate Symptom Score (I-PSS) and its significance?
I-PSS was developed by Barry et al. in 1992 and consists of 7 items. It’s also known as the AUA symptom score and is the gold standard for patient-reported outcomes in BPH. The functional scale is scored from 0–35.
What does the BPH Impact Index (BII) assess?
BII was created by Barry et al. in 1995, containing 4 items. It assesses the impact of BPH on quality of life.
Describe the ICSmale questionnaire.
The ICSmale questionnaire by Donovan et al., 2000, has 11 items and assesses voiding and continence separately.
What is unique about the Danish Prostatic Symptom Score (DAN-PSS-I)?
DAN-PSS-I, by Meyhoff et al., 1993, consists of 12 items. It generates a weighted score that accounts for urinary function and personal preferences.
What does the ICIQ-Nocturia Quality of Life Question (ICIQ-Nqol) focus on?
ICIQ-Nqol by Mock et al., 2008, includes 12 items. It is tested in both men and women, focusing on two thematic areas only, with an additional single item addressing bother caused by nocturia.
What is the BFLUTS Questionnaire, and how many items does it contain?
Designed for female incontinence; assesses numerous domains including quality of life. Contains 33 items.
What is the focus of the Bristol Female Lower Urinary Tract Symptoms (BFLUTS) Questionnaire, and how many items does it contain?
The BFLUTS Questionnaire, by Jackson et al., 1996, contains 33 items. It’s designed specifically for female incontinence and assesses numerous domains, including quality of life.
Mnemonic: Think of “BFLUTS” as “Bristol’s Fine Ladies” – a unique instrument for women.
What’s special about the International Consultation on Incontinence Questionnaire- Female Lower Urinary Symptoms (ICIQ-FLUTS)?
Modified from BFLUTS by Brookes et al., 2004. It has 12 main items and 7 additional ones, including 2 on sexual function and 5 on quality of life.
Mnemonic: “ICIQ” sounds like “I Seek” – seeking more details through additional items.
What are the IIQ and UDI, and how are they related?
The Incontinence Impact Questionnaire (IIQ) and Urogenital Distress Inventory (UDI) by Uebersax et al., 1995; Shumaker et al., 1994, contain 53 items. They capture function and bother caused by incontinence, originally for females only. Shortened versions are available.
Mnemonic: “IIQ & UDI” – Imagine “Two Unique” tools intertwined for female incontinence.
What distinguishes the Urge-Incontinence Impact Questionnaire (U-IIQ) and Urge-Urinary Distress Inventory (U-UDI)?
Created by Lubeck et al., 1999, with 42 items, these tools are similar to IIQ and UDI but weighted to assess the impact of urgency and overactive bladder symptoms.
Mnemonic: “U-IIQ & U-UDI” - “Urgent Inquiry” into urgency and overactive bladder.
What is the King’s Health Questionnaire?
Developed by Kelleher et al., 1997, it has 21 items and assesses outcomes in 10 domains, used in numerous clinical trials.
Mnemonic: “King’s Health” - A royal instrument examining ten domains like a king’s ten provinces.
What does the Incontinence Quality of Life (I-QOL) Instrument assess?
By Patrick et al., 1999; Wagner et al., 1996, with 22 items, it assesses the impact of incontinence on HRQoL in 3 domains but does not assess function.
Mnemonic: “I-QOL” - “I Question” the Quality of Life due to incontinence.
What are the key features of the Overactive Bladder Questionnaire (OAB-Q)?
Developed by Coyne et al., 2004, it includes 32 items, an 8-item symptom bother scale, and 25 HRQoL items. Generates 6 subscale scores, with 100 being better quality of life.
Mnemonic: “OAB-Q” - “Overactive Assessment Battery” - a comprehensive look at bladder issues.
What is the International Consultation on Incontinence Questionnaire (ICIQ), and how many items does it contain?
Created by Avery et al., 2004, it consists of 4 items, assessing frequency, amount, and interference of urinary leakage and what activities cause leakage.
Mnemonic: “ICIQ” - “I Consult In Quads” - 4 items for a concise insight.
What are the Symptom Severity Index (SSI) and Symptom Impact Index (SII)?
: Developed by Black et al., 1996, with 16 items, they are designed for women with stress incontinence. SSI assesses severity, while SII assesses bother and worry.
Mnemonic: “SSI & SII” - “Stress Symptom Insights” - focusing on stress incontinence.
What is CONTILIFE, and what distinguishes it?
Created by Amarenco et al., 2003, with 28 items, it’s validated in 5 languages and generates global HRQoL and 6 subscale scores, with 100 being poorer quality of life.
Mnemonic: “CONTILIFE” - “Continental Life” - a multicultural perspective on incontinence.
What is the gold standard tool for assessing male sexual dysfunction?
The International Index of Erectile Function (IIEF), by Rosen et al., 1997, with 15 items. It generates scores in erection, libido, and orgasm domains. Mnemonic: “IIEF – Incredibly Important Erectile Function.”
What tool is derived from the IIEF and specifically addresses erection?
Sexual Health Inventory for Men (SHIM), by Cappelleri et al., 2005, with 5 items. Mnemonic: “SHIM – Simply Highlighting Impotence Matters.”
Which instrument assumes the subject is heterosexual and has a partner?
QOL-MED by Wagner et al., 1996. It assesses the quality of life impact of erectile dysfunction (ED). Mnemonic: “QOL-MED – Quality Of Love, Mostly ED.”
What tool examines the psychological impact of ED without assessing function?
Psychological Impact of Erectile Dysfunction (PIED) scale by Latini et al., 2002. Mnemonic: “PIED – Psychological Impact, ED.”