T4 Test 2 Flashcards
This is the least severe form of nerve injury, temporary impairment of condition. With no significant structural change of the cell and no wallerian degeneration.
Neuropraxia
What are some causes of neurapraxia?
Mild compression injury e.g Saturday night palsy, and other entrapment neuropathy, leading to mechanical deformation of the nerve and or ischemia.
What is the prognosis of neuropraxia?
Axonal conduction and function is usually restored completely once cause of compression is identified and addressed
May need an interval of rest
May occasionally leave mild permanent damage 
What is axonotmesus?
Loss of axonal structural continuity, no loss of continuity of the Endoneurial sheath with wallerian degeneration.
What are some causes of axonotmesis?
- Can be a result of a more severe impact or stronger/more sustained compressive situation
- Neuritis, infection (Lyme, disease, toxins, diabetes related ischemia)
- Can also occur when the nerve is stretched
What is the prognosis of axonotmesis?
- may recover completely, but some degree of permanent damage is likely. affected axons may regenerate
- requires period of immobilization or modified use
- treatment according to cause possibly anti-inflammatories
Separation of the axon and damage to connective tissue. The injury may be a complete transection, proximal and distal segments or part of the nerve may remain in continuity. There is Wallerian degeneration. This is…
Neurotmesis
What are causes of neurotmesis?
Severance injuries, displacing fractures and ruptures/traction injuries. Also amputations crush injuries, industrial accidents, MVAs
Includes damage to endoneurium perineurium, and in the most severe cases the epineurium may lead to neuroma formation
What is the prognosis of neurotmesis?
- In cases involving viable distal segments, complete recovery is hypothetically possible, but unlikely. axons must regenerate
- Usually partial recovery or permanent complete loss of function
- Surgical repair, nerve graphs often required
- Immobilization often for 3 to 6 weeks and rehab required
List the connective tissue layers of the axons from outermost to innermost.
Epineurium, Perineurium, Endoneurium
What is wallerian degeneration?
The process that occurs when axon/nerve fibre is cut, severely tractioned or crushed. Which occurs in 4 stages (Degeneration, Clearance, Regeneration, Growth & re-myelination)
What is neurolemma?
Infiltration by macrophages, mast cells and Schwann cells to clear fragmented, axonal material and debris from the injury site and along the pathway of the axon
The _____ is essential for regeneration of a peripheral nerve. It should remain as a hollow tube after clearance stage to move to the regeneration stage.
Endoneurial sheath
GAP repair on average tends to last _____ days
10 to 12
Regeneration is said to occur on average at a rate of ____ per day
1 mm per day
What is neuroma?
Regenerating axons wander into surrounding tissue/scar and form, dense fibrous mass of scar tissue made up of disorganized Schwann cells, capillaries, fibroblast, macrophages, and collagen fibres at the injury site
What is neuritis?
Inflammation of a nerve
What is the regeneration frontier?
The regeneration frontier is the location of the leading tip of the new axon, It’s newly reconstructed, neurolemma and Myelin sheath during regeneration.
What can be used to locate the regeneration frontier?
Tinel’s sign
What is flaccid paralysis?
Atonia - full loss of firing
What is flaccid paresis?
Hypotonia - partial loss of firing
A partial injury is more likely to present with…
Irritable firing phenomenon
What is hyperesthesia?
Increased sensitivity to stimulation
What is paresthesia?
Spontaneous, abnormal sensations