T3 L9: The cardiac pressure-volume cycle Flashcards

1
Q

What is the circle of Willis?

A

Arteries on the inferior brain organised in a circle that provide a redundancy of blood flow

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2
Q

What % of cardiac output goes to the kidenys?

A

20-25%

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3
Q

Which organ produces ACE, Erythropoietin, and Renin?

A

The kidneys

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4
Q

What does adrenergic input do to skeletal muscle circulation?

A

Vasodilatation because muscles are associated with the fight or flight response

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5
Q

What are the 4 sequential events of the cardiac cycle?

A
  1. Ventricular filling
  2. Isovolumic ventricular contraction (Pressure is created but there is no actual contraction)
  3. Ejection (actual contraction)
  4. Isovolumic ventricular relaxation
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6
Q

What is a Wiggers diagram?

A

A cardiac diagram used to teach physiology

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7
Q

What is the Dicrotic notch?

A

A dip in a cardiac diagram indicating the closure of the aortic valve. It happens after ejection

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8
Q

What is S1 on a cardiac diagram?

A

The Lup sound. It indicated the mitral valve closing during isovolumic contraction

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9
Q

What is S2 on a cardiac diagram?

A

The dub sound. Isovolumic relaxation

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10
Q

When does the aortic valve open?

A

After isovolumic contraction (when the heart fills up). With a health heart, there wont be a sound made

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11
Q

When does the mitral valve open?

A

At the end of isovolumic relaxation (when the heart is empty)

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12
Q

When does the P wave occur?

A

Right before the heart starts filling

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13
Q

On a pressure-volume loop, describe where Ejection, Isovolumic relaxation, Isovolumic contraction and Filling are

A

IVR, ejection, IVC and filling in a clockwise direction

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14
Q

What does a pressure-volume loop look like with mitral stenosis?

A

Decreased preload and decreased afterload. The whole loop will be to the left because there is a lower volume of blood.

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15
Q

What is mitral stenosis?

A

A narrowing of the mitral valve opening

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16
Q

What does a pressure-volume loop look like with aortic stenosis?

A

Increased afterload. The aortic valve is partially closed so its much harder to pump blood out therefore the left ventricular pressure is great

17
Q

What is aortic stenosis?

A

A narrowing of the aortic valve opening

18
Q

What does a pressure-volume loop look like with mitral regurgetation?

A

High preload and decreased afterload. The is never a point when the mitral and aortic valves are fully closed so the whole diagram looks like a side ways oval

19
Q

What is mitral regurgitation?

A

The mitral valve doesn’t close

20
Q

What does a pressure-volume loop look like with aortic regurgitation?

A

Increased preload. The diagram is liver shaped.

21
Q

What is aortic regurgitation?

A

The aortic valve doesn’t close

22
Q

What is a phonocradiagram?

A

The heart sounds

23
Q

Which of the 2 heart sounds is louder?

A

The first (S1)

24
Q

What causes a murmer?

A

Turbulence

25
Q

What causes a systolic murmur?

A

Fluid leaving the ventricle. Eg. during AV regurgitation or SL stenosis

26
Q

What causes a diastolic murmur?

A

Fluid entering the ventricle. Eg, during AV stenosis or SL regurgitation

27
Q

What is the think filament made out of?

A

Actin

28
Q

What is the thick filament made out of?

A

Myosin

29
Q

Why is the cardiac action potential longer?

A

Because Ca2+ and K+ flow during the plateau phase and this doesn’t happen in neural action potentials

30
Q

What are nodal action potentials based on?

A

Flow of Ca2+

31
Q

How do delayed rectifier K+ channels work?

A

They open when the membrane depolarises but gating happens after a delay

32
Q

How do inward rectifier K+ channels work?

A

They open when the Vm gets below -60 mV( most cells open at rest). They clamp the membrane firmly at rest and allow repolarisation

33
Q

At what mV does a cell normally rest?

A

-70 mV

34
Q

What happens during depolarisation?

A

The cell becomes less negative (more positive)