T2 Ch 3 Flashcards
A genetically related abnormal drug response is called a/an:
a. drug allergy
b. idiosyncratic reaction
c. side effect
d. toxic reaction
b. idiosyncratic reaction
A drug effect that is neither predictable nor dose related is called a:
a. therapeutic effect
b. toxic reaction
c. side effect
d. drug allergy
d. drug allergy
A dose-related reaction that produces undesirable effects caused by the action on nontarget organs is called:
a. side effect
b. therapeutic effect
c. toxic reaction
d. drug allergy
a. side effect
Which of these categories of drugs would be absolutely contraindicated in a pregnant woman?
a. B
b. C
c. A
d. X
d. X
The greatest risk to the fetus from exposure to drugs occurs:
a. Before pregnancy status is known
b. During the third trimester
c. During the second trimester
d. Just before birth
a. Before pregnancy status is known
An acute, life-threatening allergic reaction characterized by hypotension, bronchospasm, laryngeal edema, and cardiac arrhythmias is what type of hypersensitivity?
a. Type II
b. Type IV
c. Type III
d. Type I
d. Type I
Which hypersensitivity reaction is termed delayed-type hypersensitivity and is mediated by sensitized T-lymphocytes and macrophages?
a. Type II
b. Type IV
c. Type I
d. Type III
b. Type IV
Type __________ hypersensitivity is mediated by IgE antibodies.
a. Type II
b. Type III
c. Type I
d. Type IV
c. Type I
A dose of a drug that kills 50% of experimental animals is termed:
a. Minimally effective dose
b. ED50
c. Therapeutic index
d. LD50
d. LD50
In an assessment of drug action for a certain therapeutic agent, results indicate that the ED50 is 3 mg/kg, and the LD50 is 300 mg/kg. What is the therapeutic index for this agent? a. 100 b. 3 c. 300 d 0.01
a. 100
True OR False
Drug allergy and a side effect are two examples of dose-related responses.
False
True OR False
Tetracycline, nonsteroidal antiinflammatory drugs (NSAIDs), and the benzodiazepines are safe to administer to a pregnant patient.
False
True OR False
The greater the therapeutic index is, the greater the toxicity will be.
False
The anatomy of what system contains long preganglionic nerves and short postganglionic nerves?
a. sensory afferent
b. somatic
c. parasympathetic autonomic
d. sympathetic autonomic
c. parasympathetic autonomic
The neurotransmitter released from a preganglionic neuron in the sympathetic division of the ANS is:
a. epinephrine
b. acetylcholine
c. dopamine
d. norepinephrine
b. acetylcholine