T helper Cells

Question 1

Th2 cell-> signature cytokines? Immune reactions? Host defense? Role in diseases?

Answer 1

Secretes-IL-4,5,13; Immune reactions- mast cell, eosinophilic activation; IgE production; “alternative” macrophage activation; Host defense- Helminthic parasites; Role in diseases: Allergic diseases

Question 2

Th17 Cell- what does it secrete? Immune reactions? Host defense? Role in disease?

Answer 2

Secretes IL-17A, 17F, 22; Immune reactions- neutrophilic, monocytic inflammation; host defense- extra cellular bacteria; fungi; Role in diseases- Organ-specific autoimmunity

Question 3

Th1 what cytokines does it release? What immune reactions is it involved with? Host Defense? Role in disease?

Answer 3

Secretes IFN-gamma, Immune reaction is macrophage activation and IgG production; Host defense- intracellular microbes; Role in diseases: Autoimmune diseases; tissue damage associated with chronic infections