Important Cytokines Flashcards
1
Q
IL-6
A
- causes fever
- stimulates produce of acute-phase proteins
- SECRETED BY MACROPHAGES
- IL-6: Stimulates aKute- phase protein production
2
Q
IL-8
A
- Major chemotactic factor for neutrophils
- “Clean up on aisle 8”
- Neutrophils are recruited by IL-8 to clear infections
- SECRETED BY MACROPHAGES
3
Q
IL-12
A
- Induces differentiation of T cells into Th1 cells
- Activates NK cell
- SECRETED BY MACROPHAGES
4
Q
TNF-alpha
A
- Mediates specific shock
- Activates endothelium
- Causes WBC recruitment, vascular leak
- SECRETED BY MACROPHAGES
5
Q
IL-2
A
- Stimulates growth of helper, cytotoxic, and regulatory T cells, and NK cells
- IL-2: stimulates T cells (T-bone)
- SECRETED BY ALL T CELLS
6
Q
IL-3
A
- Supports growth and differentiation of bone marrow stem cells
- Functions like GM-CSF (don’t need to know)
- SECRETED BY ALL T CELLS
7
Q
Interferon-gamma
A
- secreted by NK Cells and T cells in response to IL-12 from macrophages
- stimulates macrophages to kill phagocytosed pathogens
- inhibits differentiation of Th2 cells
- Activates NK cells to kill virus infected cells
- Increases MHC expression and antigen presentation by all cells
- FROM the Th1 CELLS
8
Q
IL-4
A
- Induces differentiation of T cells into Th2 cells
- Promotes growth of B cells
- Enhances class switching to IgE and IgG
- FROM Th2 CELLS
9
Q
IL-5
A
- Promotes growth and differentiation of B cells
- Enhances class switching to IgA
- Stimulates growth and differentiation of eosinophils
- FROM Th2 CELLS
10
Q
IL-10
A
- Attenuates inflammatory response
- Decreases expression of MHC class II and Th1 cytokines
- Inhibits activated macrophages and dendritic cells
- Also secreted by regulatory T cells
- TGF-beta and IL-10 both atTENuate the immune response (inhibit)
- FROM Th2 CELLS
11
Q
IL-1
A
- osteoclast- activating factor
- causes fever, acute inflammation
-activates endothelium to express adhesion molecules - Induces chemokine secretion to recruit WBCs
IL-1: fever (HOT)
-SECRETED BY MACROPHAGE
