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Hematopathology > T-Cell Lymphomas > Flashcards

T-Cell Lymphomas Flashcards

1
Q

Immature T-Cell Markers?

Mature T-Cells?

NK Cells?

Gamma-delta markers?

A

Immature: CD4/8 -, CD10+, nTdt+, CD10+

Mature: CD4 or 8+, CD3+, CD5+, CD7+

NK: CD56+, CD57+

G/D+, CD4/8 -, CD10+, CD24+

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2
Q

Angioimmunoblastic T-Cell Markers?

Genes?

A

CD4(+) T cells, CD10+/-, Bcl-6(+), CXCL13(+), PD1(+), CD21 disrupted network, EBER + nodes, EBER - skin

IDH2, DNMT3A, TET2

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3
Q

What is Lenner’ts T-cell lymphoma?

Anaplastic Large Cell Lymphoma (Ki-1) markers and gene?

A

Looks like granuloma (lymphoepithelioid cells variant); Can be CD, CD3+ and IHC shows increased T-cells

CD3+, CD5+, CD30+ (LARGE CLUSTERS), EMA+, ALK-1+, rare CD20+

t(2;5) ALK/NPM

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4
Q

What is implant associated large cell lymphoma?

CD30 + or -?

A

ALK -, diagnosis by cytology, cells grow within cavity without invasion.

**Great prognosis

Still CD30+**

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5
Q

Mycosis Fungoides markers?

Morphology?

A

CD3+, CD4>CD8+, CD3+, CD7- CD26-, Partial CD25+

Cerebriform cells in the nuclei

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6
Q

Lymphoblastic cell markers?

Adult T-cell Lymphoma morphology in blood and markers?

ATLL has what virus?

A

Precursor B: CD19+, Cd791+, Cd10+, Cd23+, tDt+

Precursor T: Cd3+, CD5+, tDt+

Flower cells: CD3(+), CD5(+), TCR-αβ/βF1(+) CD4(+), CD8(-), CD7(-), CD26(-)

HTLV1+

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7
Q

What other lab test is raised in ATLL?

Phenotype?

A

Hypercalcemia

Cd3+, CD4+, CD25+, CD8-, loss of some markers, HTLV1+

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8
Q

What are two types of enteropathy associated T-cell lymphomas?

What is associated with Celiac and HLA-DO2/DQ8?

A

Enteropathy associated T-cell lymphoma and Monomoprhic Enteropathic intestinal T-cell lymphoma

EATCL

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9
Q

Markers:
Enteropathy associated T-cell lymphoma?

Monomorphic Enteropathic Intestinal T-cell Lymphoma?

Indolent T-cell Lymphoproliferative diseases of low malignant potential?

A

CD3+, CD5-, CD4-, CD8-, CD56-, CD103+, CD30 +/-

CD3+, CD5-, CD4-, CD8-, CD56+, CD103+/-, Cd30-

Exisit and similar to above but no atypia, low mitotic index, and does not destory glands

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10
Q

Subcutaneous Pannicultitis T-Cell Lymphoma aggressive or not? Markers?

Main DDX?

A

Skin and subq nodules, both indolent and aggressive

CD1+, CD2+, CD5+, CD8+, TIA-1+, CD4-, CD56-, EBV-

Lupus

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11
Q

Hepatosplenic lymphoma?

Markers?

NK/T-cell location in body, aggressive or not, and markers?

A

Liver, spleen, LN’s but very hard to diagnose

CD1+, CD2+, CD5+, CD4/8 -, TCR-gamma+

Nasal or extra nasal, agressive, CD2+, CD3-, cCD3+/-, CD5+, CD4/8 +/-, CD57+, CD56+
EBR+ in most cases!!!

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12
Q

Angioimmunoblastic T-cell H and E?
Markers?

What other clinical and findings are common?

A

Nodal T-cell lymphoa characterized by clusters of T immunoblasts, hyperviscosity, polymorphic inflammatory infiltrate, disrupted expaned FDC’s; nodal effacement; expanded high endothelial venules

Markers: CD2 +, cCD3+ (flow might be negative), CD4 +, CD8-, CD7-, CD10+, CD21+

Findings: Polyclonal hyergammalgoulinemia and autoimmune hemolytic anemia

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13
Q

T/F Angioimmunoblastic T-cell lymphoma has T cell gene rearrangements?

It is also with what virus in the immunoblasts?

What are some genes with mutations?

A

Yes in 75%

EBV

TET2, DNMT3A, IDH2, CD28, RHOA

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14
Q

Anaplastic large cell lymphoma (Ki-1) H and E?

Markers?

Translocation?

A

Large cells with “Wreath Cells”

CD3/5+, CD30+, EMA + (60%), ALK-1 + (skin and poor prognosis -), rare CD20+, some CD138+

t(2;5) ALK/NPM

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15
Q

LGL H and E?

Markers?

What seperates LGL expansion from leukemia?

BM findings?

A

Large lymphocytes with darker nuclei in PB with granules

CD3+, CD8+, CD57+

Leukemia/Lymphoma has T-cell receptor rearrangement; worry if 80+% of flow cells are CD3+, CD8+, CD57+

BM: Erythroid hyperplasia, decreased granulopoiesis and megas

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16
Q

Precursor B markers?

Precursor T markers?

A

Pre B: CD19+, CD79a+, CD10+ (bright), CD24+, TdT+, CD20+/-, CD45-

Pre T: CD3+, CD5+, TdT+

17
Q

Flower cells are seen in, skin location?

Markers/Labs?

Virus?

A

Adult T-cell lymphoma; deep, epidermotrophism not seen

Cd3+, CD4+, CD25+, CD8-, loss CD2, CD3-, CD7-, CD5-; FoxP3+

HTLV-1

18
Q

What has Sezery cells?

Markers?

A

CTCL; MF

CD7-, CD4+, CD8+, CD7-, CD25-, CD26-, CD3+

19
Q

Gamma/Delta T cell Lymphoblastic Leukemia markers?

Hepatosplenic T-cell lymphoma H and E?

Markers?
Molecular?

A

Gamma/Delta + (best markers), CD2 dim, CD3+, CD4 variable, CD10 variable; can be hard to dx if you don’t think of it

Hepatosplenic: White cells expanding sinusoids in liver; can be in spleen (expands pulp), BM, LN (hard to dx in all sites)

Markers: CD1+, CD2+, CD3+, CD5+, CD4/CD8- (rare 8+), TCR-gamma+

Isochrom 7 or ring 7

Hematopathology (8 decks)

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