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Hematopathology > Small B-Cell Lymphomas > Flashcards

Small B-Cell Lymphomas Flashcards

1
Q

Monocyte markers?

A

CD45+, CD14+, CD114+, CD11a+, CD11b, CD16+, CD91+

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2
Q

B-cell markers?

A

CD45+, CD19+, CD20+, CD24+, CD38+, CD22+, PAX5+, CD79a+

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3
Q

NK Cell Markers

A

CD16+, CD56+, CD3-, CD31+, CD30+, CD38+

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4
Q

Pro B Markers (B-ALL)

A

Tdt+, Cd34+, CD19+, CD10+, PAX5+/-, CD20-

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5
Q

Pre-B Markers (B-ALL)

A

Has Pre BCR

Tdt+, CD34+, CD19+, CD10+, PAX5+ (different from Pro B), CD79a+, CD20-

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6
Q

Immature B-cell (B-ALL)

A

Tdt+/- (pre B and Pro B +)
CD34+/- (pre B and Pro B +)

​CD20+ (pre B and Pro B +)
CD19+
CD10+
PAX5+
CD79a+
Has some surface IgM

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7
Q 
Naive B (incluidng Ig types)
2 Cancers with this pheonotype?
A

IgM and D
TdT-

CD10+ (first time this is positive)
PAX5+
CD20+
CD79a+
Burkitt Lymphoma and Mantle

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8
Q

Centroblast (Phenotype and 1 associated cancer with phenotype)

A

CD19+
CD10+
PAX5+
CD20+
CD79a+
BCL6+ (normally found inside germinal centers)
High grade follicular lymphoma

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9
Q

Small Cell Lymphoma CD5+ CD10+?
CD5- CD10+?
CD5- and CD10-?

A

CD5+ CD10+= CLL (CD23+) or Mantle (Cyclin D1 +, CD23-)
Follicular (CD5-, CD10+)
Marginal Zone and Lymphoplasma Cytic

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10
Q

Post-transplant lymphoproliferatrive disorder associated diseases (and viral cause)?

A

EBV+
Non-=destructive PTLD, polymorphic PTLD, monomorphic PTLD, Classic Hodgkin lymphoma PTLD

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11
Q

HIV related lymphomas

A

Burkitt
Diffuse large B-cell lymphoma
Primary effusion
Plasmablastic lymphoma
Lymphoma from HHV8+ Castleman

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12
Q

CLL/SLL Phenotype
Classic Cell Morphology and Classic “finding”

A

CD19+, DIM CD20+, CD22+, CD79+, Dim IgM/D, CD5+, CD23+
CD10-, FMC7-, CyclinD1-

Clumped chromatin, scant cytoplasm (Soccer ball)
Diffuse effacement with Proliferation Centers (lack Tingible body macrophages)
Small lymphocytes, prolymphocytes, and paraimmunoblasts

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13
Q

CLL transformation into DLBCL called?

Good vs Bad CLL Prognosis genes

A

Richter syndrome (DLBCL) 2-8%, <1% into Hodgkin

Good: Mutated IGHV, Memory Like Cases, Isolated 13q14

Bad: Unmutated, Zap70+, CD38+ CD49d+, Del 11q or 17p, 13q, and more

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14
Q

What is Monoclonal B lymphocytosis?

A

Clonal B-cells with CLL phenotype
Low count: <0.5e9/L, insignificant
High: >0.5e9/L, 1-2% CLL/yr

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15
Q

B-cell Prolymphocytic leukemia (Surface antigens, affected gene, surface antigens)

A
  • *CLL with Prolymphocytes**
  • *t(11;14) or SOX11-**leukemic variant MCL

IgM/IgD, CD5+/CD23+ 25% of cases

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16
Q

Mantle Cell Lymphoma (survival rate?)
Morphology?
Phenotype?

A

5 year survival low

Small medium cell, irregular nuclei, inconspicuous nucleoli, scant cytoplasm
Mitosis common
Admixed histeocytes
CD20Bright, CD5+, CD43+, BCL2+, Cyclin D1+, SOX11+
CD10-, CD23-, BCL6-

Rare CD5- or CD23+, RARE Cyclin D1- (Cyclin D2+, SOX11+)

17
Q

Mantle Cell Lymphoma (genes/translocations)

What can it create in the colon?

Aggressive Variant?

A

IGH and IGL rearranged but unmutated
t(11;14) CCND1/BCL1 and IgH (CCND1 is cyclin D1 and can be missing)

Lymphomatous Polyposis

Blastoid (can be CD5-, CD10+, BCL6+); Pleomorphic

18
Q
A
19
Q

What is Mantle Cell In situ?

A

Preserved architecture, low grade, Cyclin D1+ confined to mantles
Most SOX11 negative

20
Q

Follicular lymphoma (phenotype, grading, translocation)?

CD21+/CD23+ meshwork, is it preserved?

A

sIg+, CD20+, CD10+, BCL6+, CD5-, CD43-

t(14;18) IGH/BCL2; 90%; BCL6 in 15%

Meshwork preserved

21
Q

Follicular Grading Criteria

Follicular Bone Marrow Finding

A

Grade 1-2 (low); 0-15 centroblasts (larger more cleared out)/hpf

Grade 3 >15 centoblasts/hpf

Grade 3A: Centrocytes present; 3B centrocytes absent

Diffuse areas of grade 3= diffuse large B-cell lymphoma

Paratrabecular aggregates

22
Q

What is duodenal-type FL?

Phenotype and Gene rearrangement?

A

Rare 2nd part of duodenum

CD20+, CD10+, CD5-, BCL6+, BCL2+

BCL2, t(14;18)

23
Q
A
24
Q

Pediatric type nodal FL (phenotype, prognosis, genes)?

A

Boys
CD10+, BCL2+, BCL2-/dim, MUM1-, CD43+/-, Ki67 high

IGH rearranged; BCL2 and 6 no translocation

Good prognosis

25
Q

Lymphoplasmacytic lymphoma (what paraprotein, survival, association)?
Waldenstrom macroglobulinemia requirements?
Morphology and Phenotype?
Gene association?

A

Indolent survival (rare DLBCL); HCV and Mast Cells

WM: LPL with bone marrow involvement and IgM monoclonal gammopathy

Diffuse interfollicular open sinsuses
Small lymphocytes, plasma cells, plasmacytoid cells (Dutcer bodies. nuclear)
CD20+bright, sIg+, cig+, CD38+, MUM1+, CD5-, CD10-, CD23-, BCL6-

MYD88; L265P

26
Q

Marginal Zone Lymphoma (Association, common location)

Morphology (also common finding)?

Phenotype?

A

Aoosciated with chronic inflammation (stomach, occular adnex, common)?

Heterogenous small-B-cells; (centrocyte-like, with cytoplasm) can represent monocytoid cells
Rare plasmacytoid diffentiation

Lymphoepithelial lesions (lymphocytes in glandular epithelium)

CD20+, CD79a+, PAX5+, CD43+/-, CD5-, CD10-

27
Q

MALT locations and translocations?
Stomach?
Intestine?
Ocular/Orbital?

Salivary Gland?
Lung?

Skin?

Thyroid?

A

Stomach: H. Pylori t(11;18) API2-MLT
Intestine: Camp jejuni mixture +3 or +18
Ocular/Orbital: C. psittaci +3
Salivary Gland: Sjogren +3

Lung: t(11;18) API2-MLT

Skin: B. Burgorferi +3
Thyroid: t(3;14), FOXP1-IgH

28
Q

Nodal MZL (where do cells reside?)

A

Adults ~60 yrs, Peripheral LN and bone marrow
Marginal zone of reactive follicles and extend into follicular region

29
Q

Splenic Marginal Zone (location?)

Classic Morphology?

Phenotype?

Mutations?

Prognosis?

A

>50 yrs, spleen, splenic hilar LN, BM, peripheral blood

Villous lymphocytes (projections on one side), small round cells replacing white pulp germinal centers, efface follicle mantle

CD20+, CD79a+, CD5-, CD10-, CD23-, CD43-, CD103-, AnnexinA1-, Cyclin D1-,m LEF1-

Deletion 7q (30%), NOTCH 2

Indolent

30
Q

Translocations
Follicular
Mantle

Marginal

A

Follicular: t(14;18)(q32;q31); IgH-BCL2

Mantle: t(11;14) (q13;q32): IgH-CCND1

Marginal: t(11;18) (q21;q21): API-MALT1

31
Q

Hairly Cell Leukemia (age, location in body, tissue patterns)

Mutation

Phenotype

Classic morphology (Peripheral blood and bone marrow)

A

Adults middle age to elderly M>W, W>B; Patchy, Diffuse solid, hypocellular

BRAF V600E

CD103+ CD11c+, DBA.44, Annexin A1+ (most specific), Trap+, CD25+, Cyclin D1+, CD123+, CD200+, CD10-, CD5-

PB: Hairly cells (projections 360 deg), BM: Fried Egg

32
Q

Hairy cell leukemia variant
Features, Phenotype

A

Leukocytosis, no monocytopenia

Round to oval nuclei, prominent nucleoi, rare cytoplasmic projections

CD103+, CD11c+, DBA.44+, T-bet+, TRAP-, CD25-, Cyclin D1-,m Annexin A1-, CD123+/-, CD200weak

Poor outcome (vs HCL which has good outocme)

Hematopathology (8 decks)

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