T Cell Interactions Flashcards
which cell type is responsible for eliminating viral infections?
CD8+ T cells
deficiency in expression of what HLA would lead to deficiency of CD8+ T cells?
HLA A, B, or C
-bc ABC are type I HLA (CD8)
what process would be interrupted in CD8 deficiency?
no positive selection for the T cells
what would lead to high IgG levels?
chronic infection
class I HLA deficiency?
lack of CD8+ T cells
recessive disorder
nonsense mutations in the TAP2 gene
acute infectious mononucleosis?
spread through saliva
-IgM and IgG antibodies against EBV capsid antigen
heterophile antibodies
produced against poorly defined antigens
what does IgG indicate?
prior infection occured
what are protective against recurrent infections?
IgG - secondary response
IgM - primary response
what happens to kill viruses?
granzyme and perforin release
what is inhibited during immunosuppression?
T cell response
umbilical cord blood transformation of B cells vs. adult ?
most adults harbor T cells specific for EBV
-infants don’t have these T cells
T cells inhibit the B cell transformation
- it kills the B cells that express antigen
- so its easier in infants
why are males with X-linked agammaglobulinemia (XLA) unable to be infected with EBV?
EBV is specific for B cells
so if you don’t got B cells, you don’t got EBV!
BUT, T cells are necessary to control EBV infection
bacteria causing leprosy?
mycobacterium leprae
mycobacterium leprae
involved in leprosy
what is best treatment for lepromatous leprosy?
if its disseminated - you have a Th2 dominant response
-spreading bc can’t contain it
treat with IFN-gamma (Th1 response)
why would an individual with lepromatous leprosy have hypergammaglobulinemia?
upregulated Th2 response would cause increased antibody production
mycobacterium leprae with a Th1 response?
tuberculoid leprosy
mycobacterium leprae with a Th2 response?
lepromatous leprosy
staphylococcus?
superantigen
what cytokine would be responsible for vascular depletion observed after superantigen infection?
TNF-alpha
secreted by T helper cells CD4
what do the superantigens activate?
V-beta region of T cell
absence of co-receptors and co-stimulation
very rapid response
cannot protect using memory immunity bc superantigens have no antigenic epitopes
**will suppress T cell responses
cytokine storm!
what is DTH response associated with?
granuloma formation
IFN-gamma receptor deficiency?
no macrophage response
IFN-gamma deficiency similar to what?
IL-12 deficiency
