T Cell Interactions

Question 1

which cell type is responsible for eliminating viral infections?

Answer 1

CD8+ T cells

Question 2

deficiency in expression of what HLA would lead to deficiency of CD8+ T cells?

Answer 2

HLA A, B, or C

-bc ABC are type I HLA (CD8)

Question 3

what process would be interrupted in CD8 deficiency?

Answer 3

no positive selection for the T cells

Question 4

what would lead to high IgG levels?

Answer 4

chronic infection

Question 5

class I HLA deficiency?

Answer 5

lack of CD8+ T cells

recessive disorder

nonsense mutations in the TAP2 gene

Question 6

acute infectious mononucleosis?

Answer 6

spread through saliva

-IgM and IgG antibodies against EBV capsid antigen

Question 7

heterophile antibodies

Answer 7

produced against poorly defined antigens

Question 8

what does IgG indicate?

Answer 8

prior infection occured

Question 9

what are protective against recurrent infections?

Answer 9

IgG - secondary response

IgM - primary response

Question 10

what happens to kill viruses?

Answer 10

granzyme and perforin release

Question 11

what is inhibited during immunosuppression?

Answer 11

T cell response

Question 12

umbilical cord blood transformation of B cells vs. adult ?

Answer 12

most adults harbor T cells specific for EBV
-infants don’t have these T cells

T cells inhibit the B cell transformation

• it kills the B cells that express antigen
• so its easier in infants

Question 13

why are males with X-linked agammaglobulinemia (XLA) unable to be infected with EBV?

Answer 13

EBV is specific for B cells

so if you don’t got B cells, you don’t got EBV!

BUT, T cells are necessary to control EBV infection

Question 14

bacteria causing leprosy?

Answer 14

mycobacterium leprae

Question 15

mycobacterium leprae

Answer 15

involved in leprosy

Question 16

what is best treatment for lepromatous leprosy?

Answer 16

if its disseminated - you have a Th2 dominant response
-spreading bc can’t contain it

treat with IFN-gamma (Th1 response)

Question 17

why would an individual with lepromatous leprosy have hypergammaglobulinemia?

Answer 17

upregulated Th2 response would cause increased antibody production

Question 18

mycobacterium leprae with a Th1 response?

Answer 18

tuberculoid leprosy

Question 19

mycobacterium leprae with a Th2 response?

Answer 19

lepromatous leprosy

Question 20

staphylococcus?

Answer 20

superantigen

Question 21

what cytokine would be responsible for vascular depletion observed after superantigen infection?

Answer 21

TNF-alpha

secreted by T helper cells CD4

Question 22

what do the superantigens activate?

Answer 22

V-beta region of T cell

absence of co-receptors and co-stimulation

very rapid response
cannot protect using memory immunity bc superantigens have no antigenic epitopes

**will suppress T cell responses
cytokine storm!

Question 23

what is DTH response associated with?

Answer 23

granuloma formation

Question 24

IFN-gamma receptor deficiency?

Answer 24

no macrophage response

Question 25

IFN-gamma deficiency similar to what?

Answer 25

IL-12 deficiency