T Cell Differentiation Flashcards
1
Q
Where are T cells produced
A
In the bone marrow
2
Q
Where do T cells mature
A
In the thymus
3
Q
Can DiGeorges disease be cured with BMT
A
No, the thymus is missing so the t cells cannot mature
Ie need thymus transplant
4
Q
In the thymus positive selection happens where
A
In the cortex
5
Q
Positive selection does what
A
It checks the TCRs and if it can bind self MHC appropriately it is allowed to move on
6
Q
Negative selection occurs in what
A
The medulla of the thymus
