Major B+T Cell Fx Flashcards
B and T cells are what type of immunity
Adaptive
B cells are what branch of adaptive immunity
Humoral
How does a B Cell work
Recognizes and presents the antigen, somatic hypermutation happens to ensure ID of antigen, production of Antibody/Ig after they become plasma cells
What retains the ability to ID infections?
B memory cells
T cells are what branch of immunity
Cell mediated
T cell mechanisms
Th1+2 help B cells make antibodies by being part of costimulation
Also help them release the cytokines to recruit phagocytes and activate other WBC
T helper cells have what MHC/CD
T helpers have CD4 and are MHC2
Cytotoxic T cells have what CD/MHC
CD8 and MHC1
What type of hypersensitivity are T cells involved in
Type 4 hypersensitivity, or DTH (Delayed Type Hypersensitivity)
T cells can affect transplants how
By causing acute and chronic organ rejection
How do Tcytotoxic cells work
They use the same pathway as NK cells (perforin>granzyme>DNA>BAX>BCL2 removal from mitochondria>cytochrome C and caspase destruction