T-1B-B-The Extracellular Matrix Flashcards
This surrounds the body tissues
Extracellular matrix
other name for body tissues
connective tissues
few things ecm does
- guides cells
- networks cells
- relays signals
3 impotance of ecm
- elasticity
- protection
- involvement of processes
3 classes of biomolecules
- structural proteins
- specialized proteins
- proteoglycans
most abundant protein in the animal world. has 19 types.
Collagen
how many residue does collagen have
3.3 residue (triple helix)
smallest amino acid
glycine
how many types of collagens are there
5 types
Type I collagen
bone, skin, dentin, blood vessels, fibrocartilage, and tendon
Type II collagen
Cartilaginous tissue
Tyype III
Skin, ligaments, blood vessels, and internal organs
Type IV
basement membrane of various tissues
Tpe V
Blood vessel wall, synovium, corneal stroma, tendon, lung, bone, and skletal muscle
proline turns to hydoxyproline because of this acid
ascorbic acid
important factor in determining strength of collagen
hydroxylation of proline
what is triggers lysine residue to hyroxylysine
oxidative deamination with copper
Ehlers- Danlos syndrome
hyperextensibility of the skin, abnormal tissue, fragile. type IV and VI effected
Epidermolysis bullosa
skind breaks due to minor trauma. type VII effected
Scurvy
ascorbic acid deficiency
the primary sequence for collagen protein synthesis is coded in
DNA
no hydroxylysine
no triple helix
no repeating structure
no carbohydrate
Elastin
has intramolecular aldon cross links
collagen
is fibronectin involved in the migration of cells? T or F
True. it is involved in the migration of cells
what does the glomular filtrate
urine
fluid that filters through glomeruli into bowmans capsule
Glomerular filtrate
are amino acids and plasma proteins excreted into the urine?
no. amino acids and plasma are reabsorbed
what is the normal value of glomerular filtrate rate
125ml/min or 180 liter/day
leakage of proteins in the urine
glomerulonephritis
this is a glycoaminoglycans connected to a core protein molecule
Proteoglycans
Can proteoglycans hold large amount of water?
T or F
True
composed of type I collagen with Type V collagen in small amounts
Bones
major cells involved in the bone resorption and deposition
osteoclasts and osteblats
for bone resorption
osteclasts
for bone deposition
osteoblasts
descendants of osteoblats and help in bone matrix
osteocytes
Osteopetrosis
marble bone disease - inability to resorb
osteoporosis
imbalance in reorption and deposition
osteogenesis imperfecta
brittle bones - sclere of eye is thin
rickets
bones lack to calcify
due to lack of calcium
major proteoglycan in cartilage is
aggrecan
major collagen component in cartilage
Collagen type II
3 types of cartilages
Hyaline
Elastic
fibroelastic
Chondroplasia
hereditary. short limb dwarfism due to failure of devlp. cartilages
ECM is also important in producing cancer cells T or F
True
normal joints have this fluid
synovial fluid
arthritis have synovial fluid T or F
False
