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Infection & Immunology > Systemic Lupus Erythematosus > Flashcards

Systemic Lupus Erythematosus Flashcards

1
Q

Define Systemic Lupus Erythematosus (SLE)?

A

Multi-system inflammatory autoimmune disorder

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2
Q

How do we diagnose SLE?

A

4/11 of the diagnostic criteria fo the American College of Rheumatology provides high sensitivity and specificity for the diagnossi of SLE

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3
Q

What is the crtieria for the diagnosis of SLE?

A 
SOAP BRAIN MD
Serositis 
Oral Ulcers
Arthritis (non-erosive)
Photosensitivity 
Bloods (haemolytic anaemia/leukopaenia/thrombocytopaenia)
Renal disease (urine casts/proteinuria)
ANA 
Immunological disorder (anti-dsDNA/anti-Sm/anti-phospholipid)
Neurological disease (psychosis/seizures)
Malar rash 
Discoid rash
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4
Q

What is the aetiology of SLE?

A

Tissue damage may be caused by vascular immune complex deposition
Could be due to a combination of hormonal, genetic and exogenous factors

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5
Q

What is the epidemiology of SLE?

A 
COMMON 
1-2/1000
More common in the YOUNG 
More common in Afro-Caribbean and CHINESE 
9x more common in FEMALES
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6
Q

What are the presenting symptoms and signs of SLE?

A 
General Symptoms 
Raynaud's Phenomenon 
Oral ulcers
Skin Rash
Systemic symptoms
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7
Q

What are the general symptoms of SLE?

A 
Fever 
Fatigue 
Weight Loss 
Lymphadenopathy
Splenomegaly
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8
Q

What are the different types of rash that show in SLE?

A 
Malar rash 
Discoid lupus (red scaly patches)
Atypical rashes (e.g. photosensitivity, vasculitis, urticaria, purpura)
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9
Q

What are the musculoskeletal systemic symptoms of SLE?

A

Arthritis
Tendonitis
Myopathy

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10
Q

What are the Cardiac Systemic symptoms of SLE?

A

Pericarditis
Myocarditis
Arrhythmias
Libman-Sacks endocarditis

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11
Q

What are the Lung-related Systemic Symptoms of SLE?

A

Pleurisy
Pleural effusion
Basal atelectasis
Restrictive lung defects

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12
Q

What are the Neurological Systemic Symptoms of SLE?

A 
Headache 
Stroke 
Cranial Nerve Palsies
Confusion 
Chorea
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13
Q

What are the Psychiatric Systemic symptoms of SLE?

A

Depression

Psychosis

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14
Q

What are the Renal Systemic Symptoms of SLE?

A

Glomerulonephritis

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15
Q

What investigations do you do for SLE?

A 
Bloods 
Autoantibodies 
Urine 
Joint investigations
Heart and Lungs investigations
Kidney investigations
CNS investigations
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16
Q

What bloods do we do for SLE and what might we see?

A 
FBC 
U&Es 
LFT 
Raised ESR
Normal CRP
Clotting 
Complement
17
Q

What autoantibodies do we see for SLE?

A 
Anti-dsDNA (60%)
Rheumatoid factor (30-50%)
Anti-ENA
Anti-RNP
Anti-SM
Anti-Ro
Anti-La
Anti-histone 
Anti-cardiolipin
18
Q

What do we see in the urine for SLE?

A

Haematuria
Proteinuria
Red cell casts

19
Q

What joint investigations do we do for SLE?

A

Plain radiographs

20
Q

What heart and lung investigations do we do for SLE?

A

CXR
ECG
Echocardiogram
CT

21
Q

What kidney investigations do we do for SLE?

A

Renal biopsy (if glomerulonephritis suspected)

22
Q

What CNS investigations do we do for SLE?

A

MRI scan

Lumbar puncuture

Infection & Immunology (40 decks)

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