Systemic Lupus Erythematosus Flashcards
All of the following are TRUE about epidemiology of SLE EXCEPT:
A. 30% of patients are women of child-bearing years
B. Prevalence is higher in all white races
C. 2-3.5 times more prevalent in women than men
D. All of the options
D. All of the options
Which of the following autoantibodies is specific to SLE and has no definite clinical correlations?
A. ANA
B. Anti-dsDNA
C. Anti-Sm
D. Anti-C1q
E. Anti-RNP
C. Anti-Sm
All of the following are TRUE about ANA EXCEPT:
A. Best screening test
B. Immunofluorescence is best standard test
C. Has good specificity but poor sensitivity
D. None of the options
C. Has good specificity but poor sensitivity
All of the following increases the risk for SLE EXCEPT:
A. Tobacco smoking
B. Alcohol
C. Exposure to crystalline silica
D. Exposure to UV rays
E. Long term exposure to air pollution
B. Alcohol
SLE biopsies reveal all of the following EXCEPT:
A. deposition of Ig at the DEJ
B. injury to basal keratinocytes
C. Inflammation dominated by B lymphocytes in the DEJ
D. None of the options
C. Inflammation dominated by B lymphocytes in the DEJ
All of the following classes of lupus nephritis are treated with aggressive immunosuppression EXCEPT:
A. Class III
B. Class IV
C. Class V w/ III or IV
D. Class VI
E. None of the options
D. Class VI
Involves glomerulonephritis involving <50% of all glomeruli
A. Class I (Minimal Mesangial)
B. Class II (Mesangial Proliferative)
C. Class III (Focal)
D. Class IV (Diffuse)
E. Class V (Membranous)
C. Class III (Focal)
All of the following are chronic cutaneous skin manifestations of SLE EXCEPT:
A. Discoid rash
B. Lichen planus-like
C. Bullous
D. Chillblains
E. Panniculitis
C. Bullous
Thrombocytopenia in SLE is described as which of the following?
A. <200,000/uL
B. <150,000/uL
C. <100,000/uL
D. <50,000/uL
E. <10,000/uL
C. <100,000/uL
If pain persists in a single joint, such as knee, shoulder, or hip, a diagnosis of which of the following should be considered?
A. SLE
B. Arthritis
C. Rhupus
D. Ischemic necrosis of bone
D. Ischemic necrosis of bone
Most common chronic dermatitis in lupus
A. Discoid
B. Panniculitis
C. Verrucous
D. Chillblains
A. Discoid
Butterfly rash
A. Acute
B. Subacute
C. Chronic
D. Any of the options
A. Acute
Annular lesions
A. Acute
B. Subacute
C. Chronic
D. Any of the options
B. Subacute
Most serious manifestation of SLE
A. Pericarditis
B. Nephritis
C. Pleuritis
D. Seizures
B. Nephritis
Most common manifestation of diffuse CNS lupus
A. Seizure
B. Psychosis
C. Cognitive dysfunction
D. Delirium
C. Cognitive dysfunction
Which of the following is the most frequent hematologic manifestation of SLE?
A. Hypochromic, microcytic anemia
B. Hyperchromic, macrocytic anemia
C. Normochromic, normocytic anemia
D. Hypochromic, normocytic anemia
E. Hyperchromic, normocytic anemia
C. Normochromic, normocytic
All of the following are hematologic manifestations of SLE EXCEPT:
A. Leukopenia
B. Lymphopenia
C. Lymphadenopathy
D. Splenomegaly
E. Granulocytopenia
E. Granulocytopenia
Which of the following is the common adverse effect of using salicylates?
A. Aseptic meningitis
B. Elevated liver enzymes
C. Ototoxicity
D. Dermatitis
D. Nephrotoxicity
C. Ototoxicity
Which of the following drugs can be used if the patients are resistant to conservative management?
A. Azathioprine
B. Cyclophosphamide
C. DHEA
D. Mycophenolate mofetil
E. Rituximab
E. Rituximab
Withdrawal of this antimalarial drug results in increased numbers of SLE flares
A. Hydroxychloroquine
B. Chloroquine
C. Quinacrine
D. All of the options
A. Hydroxychloroquine
Diarrhea is more common in which of the following drugs?
A. Cyclophosphamide
B. Mycophenolate mofetil
C. Methotrexate
D. Hydroxychloroquine
B. Mycophenolate mofetil
Which of the following drugs is considered as safe for pregnant women with SLE?
A. Mycophenolate
B. Cyclophosphamide
C. Methotrexate
D. Hydroxychloroquine
D. Hydroxychloroquine
All of the following drugs may induce lupus EXCEPT:
A. Procainamide
B. Hydralazine
C. Propylthiouracil
D. Carbamazepine
E. None of the options
E. None of the options
All of the following are TRUE about Scleroderma EXCEPT:
A. Unknown cause
B. Overproduction of collagen and ECM proteins
C. Men are 3x affected than women
D. Peaks in the 3rd to 5th decade
E. None of the options
C. Men are 3x affected than women
All of the following are features of CREST syndrome EXCEPT:
A. Calciphylaxis
B. Raynaud’s phenomenon
C. Esophageal dysmotility
D. Sclerodactyly
E. Telangiectasias
F. None of the options
A. Calciphylaxis
Dermatomyositis is dominated by which of the following?
A. RBCs
B. Platelets
C. Lymphocytes
D. Neutrophils
C. Lymphocytes
All of the following are TRUE about dermato-polymyositis EXCEPT:
A. Symmetrical weakness of limb girdle muscle
B. Pathognomonic heliotrope
C. Presence of Shawl sign (erythema over the back and shoulders)
D. Muscle biopsy show type I and II fiber necrosis
E. None of the options
B. Pathognomonic heliotrope
All of the following are TRUE about drug-induced lupus EXCEPT:
A. Rarely associated with antibodies to histones
B. Least common offenders include hydralazine, isoniazid, procainamide and sulfasalazine
C. Has female predilection like that of SLE
D. ANA usually appears after symptoms
E. All of the options
E. All of the options
Which of the following is the most serious ocular manifestation of SLE?
A. Keratoconjunctivitis
B. Xerostomia
C. Retinal vasculitis
D. Sicca syndrome
E. None of the options
C. Retinal vasculitis
Which of the following is the mainstay therapy of not organ threatening SLE?
A. Analgesics and antimalarials
B. NSAIDs only
C. Systemic glucocorticoids
D. Oral and systemic glucocorticoids
E. Any of the options
A. Analgesics and antimalarials
