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CIMS > Myasthenia Gravis > Flashcards

Myasthenia Gravis Flashcards

1
Q

Which of the following is true about Edrophonium?

A. Initial dose of 3mg
B. Reversible AChE inhibitor
C. Atropine is given to reverse the worsening symptoms
D. Any of the options

A

D. Any of the options

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2
Q

Which of the following is true about Neostigmine?

A. Destroyed by plasma esterases
B. Reversible AChE inhibitor
C. Has a greater effect on skeletal muscles
D. Any of the options

A

D. Any of the options

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3
Q

All of the following are quaternary amines EXCEPT:

A. Neostigmine
B. Pyridostigmine
C. Edrophonium
D. Physostigmine

A

D. Physostigmine - tertiary amine

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4
Q

Which of the following is considered as short-acting cholinesterase inhibitors?

A. Edrophonium
B. Neostigmine
C. Pyridostigmine
D. Physostigmine

A

A. Edrophonium

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5
Q

Which of the following is considered as intermediate-acting cholinesterase inhibitors?

A. Edrophonium
B. Neostigmine
C. Echothiopate
D. Any of the options

A

B. Neostigmine

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6
Q

Which of the following is considered as long-acting cholinesterase inhibitors?

A. Malathion
B. Neostigmine
C. Echothiopate
D. Any of the options

A

D. Any of the options (Echothiopate, malathion, parathion)

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7
Q

All organophosphates are generally well absorbed from the skin, lung, guts, conjunctiva, and CNS EXCEPT:

A. Echothiopate
B. Malathion
C. Parathion
D. Any of the options

A

A. Echothiopate

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8
Q

Which of the following is/are TRUE about long-acting cholinesterase inhibitors?

A. Have limited half-life
B. Reversible AChE inhibitors
C. CNS toxicity is an important component of poisoning with these agents
D. Any of the options

A

D. Any of the options (A and C are TRUE)

Short and immediate acting - REVERSIBLE
Long acting - IRREVERSIBLE

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9
Q

Which of the following should you opt to use for intermediate-term therapy of MG?

A. Prednisone + Cyclosporine
B. Azathioprine + Mycophenolate mofetil
C. Prednisone + Mycophenolate mofetil
D. Any of the options

A

A. Prednisone + Cyclosporine

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10
Q

Which of the following should you opt to use for long-term therapy of MG?

A. Prednisone + Cyclosporine
B. Prednisone + Tacrolimus
C. Azathioprine + Mycophenolate mofetil
D. Any of the options

A

C. Azathioprine + Mycophenolate mofetil

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11
Q

The MOA of this drug includes inhibition of proliferation if lymphocytes but not the proliferation of other cells

A

Mycophenolate mofetil

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12
Q

This drug is used to reduce the dosage of prednisone to control necessary symptoms

A

Azathioprine

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13
Q

Which of the following is FALSE about Cyclosporine?

A. Considered as calcineurin inhibitor
B. Inhibits IL-1 and IL-2 receptor productions
C. Works more slowly than Azathioprine and Mycophenolate mofetil
D. Any of the options

A

C. Works FASTER than azathioprine and mycophenolate mofetil

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14
Q

This drug is a chimeric monoclonal antibody that binds to the CD20 molecule on B lymphocytes

A

Rituximab

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15
Q

Which of the following drugs is considered to be more effective in MuSK antibody-positive MG?

A. Azathioprine
B. Cyclosporine
C. Rituximab
D. Mycophenolate mofetil

A

C. Rituximab

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16
Q

This drug is a humanized IgG monoclonal antibody that binds to the C5 complement pathway

A

Eculuzimab

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17
Q

What drug is contraindication with Azathioprine?

A. Allopurinol
B. Colchicine
C. Rituximab
D. Any of the options

A

A. Allopurinol

18
Q

At high doses, this drug eliminates mature lymphocytes but spares hematopoietic precursors

A

Cyclophosphamide

19
Q

Which is the first line of drug for MG

A

Pyridostigmine

20
Q

MG is characterized more of which of the ff:

A. Benign thymoma
B. Malignant thymoma
C. Thymic hyperplasia
D. Any of the options

A

C. Thymic hyperplasia (75%)

21
Q

Problem in airways (asthma) is considered as ________ (obstructive/restrictive) disease.

A

Obstructive

22
Q

Problem in lung expansion (pulmonary fibrosis) is considered as ________ (obstructive/restrictive) disease.

A

Restrictive

23
Q

Problem in trachea is considered as ________ (obstructive/restrictive) disease.

A

Obstructive

24
Q

Edrophonium effects involve all of the ff EXCEPT:

A. Pupillary dilation
B. Increased salivation
C. Bradycardia
D. Any of the options

A

A. Pupillary CONSTRICTION

25
Q

This is the specific test for MG

A

Anti AChR

26
Q

Most sensitive test for NMJ disorders

A

ANA

27
Q

Most sensitive diagnostic test for MG

A

SFEMG

28
Q

What disease involves the complaint of fatigue, with tiredness or apathy rather than decreasing muscle power on repeated effort?

A

Neurasthenia

29
Q

Which of the following clinical manifestations separate MG from Botulism?

A. Diplopia
B. Reduced salivation
C. Pupillary dilation
D. Any of the options

A

B. and C.

30
Q

Which of the ff decreases the acetylcholine release?

A. Potassium
B. Sodium
C. Calcium
D. Magnesium

A

D. Magnesium

31
Q

What ocular muscle is involved in ptosis?

A

Levator palpebrae superioris

32
Q

What EOM are involved in diplopia?

A

Superior rectus and Inferior oblique

33
Q

It is a syndrome that is caused by antibodies that block ACh release by inhibiting a presynaptic CALCIUM channel

A

LEMS

34
Q

What is the most sever complication of MG?

A

Respiratory failure

35
Q

What type of hypersensitivity is MG?

A

Type II

36
Q

Lambert-Eaton syndrome is a neuromuscular junction disorder causing (proximal/distal ________ muscle weakness.

A

proximal

37
Q

Lambert-Eaton syndrome is commonly associated with

_________ of the lung and is characterized by muscle weakness of the limbs.

A

small cell carcinoma

38
Q

The diagnosis of Lambert-Eaton myasthenic syndrome is established by performing _________ electrodiagnostic study.

A

repetitive nerve stimulation

39
Q

_____________ is used for the management of Lambert-Eaton myasthenic syndrome in patients resistant to symptomatic treatment.

A

Intravenous immunoglobulin

40
Q

______ is the first line treatment for botulism

A

Antitoxin (HEPTA, BIG-IV)

CIMS (6 decks)

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