Psoriasis Flashcards
Psoriasis is characterized by which of the following?
A. Silvery scale
B. Papules
C. Plaques
D. All of the options
D. All of the options
Psoriasis is an immune-mediated disease clinically characterized by erythematous, sharply demarcated papules and rounded plaques covered by silvery micaceous scale.
Psoriasis is exacerbated by which of the following?
A. Infections B. Antimalarial drugs C. Beta blockers D. Two of the options E. All of the options
E. All of the options
Other external factors may exacerbate psoriasis, including infections, stress, and medications (lithium, beta blockers, and antimalarial drugs).
Most common variety of psoriasis
Plaque-type psoriasis / psoriasis vulgaris
The most commonly affected areas involved in plaque-type psoriasis are all of the following EXCEPT:
A. Elbows B. Knees C. Scalp D. Two of the options E. None of the options
E. None of the options
The most commonly involved areas are the ELBOWS, KNEES, GLUTEAL CLEFT, and SCALP.
Which of the following is TRUE about plaque-type psoriasis?
A. Asymmetric B. Develops fast C. Stable plaques D. Runs an indolent course E. Two of the options
E. Two of the options
Patients with plaque-type psoriasis have STABLE, slowly ENLARGING PLAQUES. Involvement tends to be SYMMETRIC. Generally develops slowly and RUNS AN INDOLENT COURSE.
What type of psoriasis is most common in CHILDREN?
Guttate/Eruptive psoriasis
What type of psoriasis is most common in YOUNG ADULTS?
Guttate/Eruptive psoriasis
This type of psoriasis affects the axilla, groin, submammary region, and navel
Inverse psoriasis
All of the following is TRUE about inverse psoriasis EXCEPT:
A. Affects the scalp B. Affects the palms and soles C. May be moist D. Presence of scale E. None of the options
D. Presence of scale
Inverse psoriasis tends to affect the SCALP, PALMS, and SOLES. The individual lesions are sharply demarcated plaques, but they may be MOIST and WITHOUT SCALE due to their locations.
Which of the following has the differential diagnosis of pityriasis rosea and secondary syphilis?
A. Inverse psoriasis
B. Guttate psoriasis
C. Pustular psoriasis
D. Plaque-type psoriasis
B. Guttate psoriasis
Which of the following is easily confused with eczema?
A. Inverse psoriasis
B. Guttate psoriasis
C. Pustular psoriasis
D. Plaque-type psoriasis
C. Pustular psoriasis
Treatment/s of choice for pustular psoriasis
A. Glucocorticoids B. Oral retinoids C. IV retinoids D. Two of the options E. All of the options
B. Oral retinoids
Which of the following is TRUE about psoriatic arthritis?
A. 30% of the patients with psoriasis have PsA
B. There are five subtypes of PsA
C. Symmetric PsA may present as “sausage digits”
D. Two of the options
E. All of the options
D. Two of the options
30% of the patients with psoriasis have PsA
Five subtypes of PsA: symmetric, asymmetric, distal, spondylitis, and arthritis mutilans
Symmetric - 50%; resembles RA
Asymmetric - Sausage digits
Distal - classic form; dystrophic, including nail pitting
Spondylitis - 5%
Arthritis mutilans - severe and deforming; affect small joins of hands and feet
Which if the following presents acanthosis and vascular proliferation?
A. Psoriasis
B. Lichen planus
C. Pityriasis rosea
D. Dermatophytosis
A. Psoriasis
Which if the following presents interface dermatitis
A. Psoriasis B. Lichen planus C. Pityriasis rosea D. Dermatophytosis E. Any of the options
B. Lichen planus
Which if the following presents hyphae and neutrophils in stratum corneum?
A. Psoriasis B. Lichen planus C. Pityriasis rosea D. Dermatophytosis E. Any of the options
D. Dermatophytosis
Which if the following presents purple polygonal papules marked by severe pruritus and has lacy white markings?
A. Psoriasis B. Lichen planus C. Pityriasis rosea D. Dermatophytosis E. Any of the options
B. Lichen planus
Which if the following presents a rash often preceded by a patch with a “fir tree-like” appearance?
A. Psoriasis B. Lichen planus C. Pityriasis rosea D. Dermatophytosis E. Any of the options
C. Pityriasis rosea
Which if the following presents a mica-like scale?
A. Psoriasis B. Lichen planus C. Pityriasis rosea D. Dermatophytosis E. Any of the options
A. Psoriasis
Which of the following topical agents are vitamin D analogue?
A. Tazarotene B. Calcipotriene C. Anthralin D. Coal tar E. Any of the options
B. Calcipotriene
Tazarotene - Retinoid
Which of the following can be used as effective therapy for patients with widespread psoriasis?
A. UVB B. narrowband UVB C. UVA + psoralens D. Two of the options E. All of the options
E. All of the options
UV light therapy is contraindicated in patients receiving what drug?
A. Salicylic acid
B. Anthralin
C. Cyclosporine
D. Any of the options
C. Cyclosporine
Which of the following psoriasis medication is a retinoid?
A. Methotrexate
B. Acitretin
C. Cyclosporine
D. Apremilast
B. Acitretin
Methotrexate - Antimetabolite
Cyclosporine - Calcineurin inhibitor
Apremilast - Phosphodiesterase type 4 inhibitor
This is an inflammatory autoimmune-related disease characterized by inflammation and keratinocyte proliferation.
Psoriasis
What type of psoriasis is affected by streptococcal infection such as pharyngitis?
A. Inverse psoriasis
B. Guttate psoriasis
C. Pustular psoriasis
D. Plaque-type psoriasis
B. Guttate psoriasis
Diagnostic FEATURE of plaque type psoriasis in which new lesions appear at sites of trauma
Koebner phenomenon
Removal of scales in plaque type psoriasis may result in _________
Pinpoint bleeding (Auspitz sign)
Nail involvement, a valuable diagnostic SIGN, is characterized by pitting of the nail plate, called __________
Oncholysis
What is the first tier treatment for psoriasis?
Topical therapy
What is the first-line topical option for psoriasis?
Emollients, vitamin D analogs (calcipotriene or calcitriol), and mid to high potency corticosteroids
What is the second-line topical option for psoriasis?
Retinoids (tazarotene) tar, anthralin, salicylic acid
What is the second tier treatment for psoriasis?
phototherapy;
Which of the ff is the most effective phototherapy?
A. UVB B. Narrowband UVB C. UVA D. PUVA E. Any of the options
D. PUVA = UVA + psoralens
What is the first-line systemic agent for children with psoriasis?
Methotrexate (0.2-0.7 mg/kg/wk)
Which of the following TNF inhibitors has/have FDA approval and can be used for pediatric psoriasis?
A. Etanercept B. Infliximab C. Adalimumab D. Two of the options E. All of the options
A. Etanercept
Which of the following associated metabolic syndrome correlates with psoriasis severity?
A. Hyperglycemia B. Hyperlipidemia C. Hypertension D. Two of the options E. All of the options
E. All of the options
Which of the following is considered as the safest long-term topical antipsoriatic treament?
A. Glucocorticoids
B. Vitamin D derivatives
C. Calcineurin inhibitors
D. UV exposure
B. Vitamin D derivatives
Which of the following is most widely used biological response modifier as antipsoriatic therapy?
A. Etanercept B. Adalimumab C. Infliximab D. Ustekinumab E. Secukinumab
B. Adalimumab
Which of the following can be a treatment for impetigo?
A. Antistaphylococcal antibiotics
B. Topical azoles
C. Topical selenium sulfide lotion
D. Any of the options
A. Antistaphylococcal antibiotics
Impetigo - Group A strep and S. aureus
Which of the following is TRUE about psoriasis?
A. Affects up to 2% of the world's population B. Immune-mediated disease C. Characterized by erythematous papules D. Two of the options E. All of the options
E. All of the options
Pathology of fully developed psoriasis lesions is characterized by which of the following?
A. uniform elongation of rete ridges B. thinning of suprapapillary plate C. intermittent parakeratosis D. two of the options E. all of the options
E. All of the options
This form of psoriasis has the strongest association to HLA-Cw6
Guttate/eruptive psoriasis
